Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, PR China.
J Agric Food Chem. 2023 Jul 26;71(29):10932-10951. doi: 10.1021/acs.jafc.3c02787. Epub 2023 Jul 11.
Hydroxycinnamic acid derivatives (HCDs) are polyphenols that are abundant in cereals, coffee, tea, wine, fruits, vegetables, and other plant-based foods. To aid in the clinical prevention and treatment of Parkinson's disease (PD), we evaluated in vivo investigations of the pharmacological properties of HCDs relevant to PD, and their pharmacokinetic and safety aspects. An extensive search of published journals was conducted using several literature databases, including PubMed, Google Scholar, and the Web of Science. The search terms included "hydroxycinnamic acid derivatives," "ferulic acid," "caffeic acid," "sinapic acid," "p-coumaric acid," "Parkinson's disease," and combinations of these keywords. As of April 2023, 455 preclinical studies were retrieved, of which 364 were in vivo studies; we included 17 of these articles on the pharmaceutics of HCDs in PD. Available evidence supports the protective effects of HCDs in PD due to their anti-inflammatory, antioxidant, as well as antiapoptotic physiological activities. Studies have identified possible molecular targets and pathways for the protective actions of HCDs in PD. However, the paucity of studies on these compounds in PD, and the risk of toxicity induced with high-dose applications, limits their use. Thus, multifaceted studies of HCDs in vitro and in vivo are needed.
羟基肉桂酸衍生物（HCDs）是一类多酚类物质，广泛存在于谷物、咖啡、茶、酒、水果、蔬菜和其他植物性食物中。为了帮助临床预防和治疗帕金森病（PD），我们评估了与 PD 相关的 HCDs 的药理学特性、药代动力学和安全性方面的体内研究。使用多个文献数据库，包括 PubMed、Google Scholar 和 Web of Science，对已发表的期刊进行了广泛的搜索。检索词包括“羟基肉桂酸衍生物”、“阿魏酸”、“咖啡酸”、“芥子酸”、“对香豆酸”、“帕金森病”以及这些关键词的组合。截至 2023 年 4 月，共检索到 455 项临床前研究，其中 364 项为体内研究；我们纳入了 17 篇关于 HCDs 在 PD 中的药剂学的文章。现有证据支持 HCDs 在 PD 中的保护作用，这与其抗炎、抗氧化和抗细胞凋亡的生理活性有关。研究已经确定了 HCDs 在 PD 中保护作用的可能分子靶点和途径。然而，由于缺乏这些化合物在 PD 中的研究，以及高剂量应用可能引起的毒性风险，限制了它们的应用。因此，需要对 HCDs 进行体外和体内的多方面研究。
