Faculty, Department of Pharmaceutical Sciences, Panipat Institute of Engineering & Technology (PIET), Samalkha, Haryana 132102, India.
Faculty, Department of Pharmaceutical Sciences, Chandigarh Group of Colleges (CGC), Landran, Sahibzada Ajit Singh Nagar, India.
Curr Top Med Chem. 2022;22(18):1515-1529. doi: 10.2174/0929866529666220426121324.
P-coumaric acid is a common dietary polyphenol present in fruits, vegetables, and cereals in conjugated and free form. The toxicity profile of the drug is very low, and it exhibits many pharmacological actions (antihypertensive, anti-inflammatory, anticancer, antimicrobial activity, antidiabetic, anticancer, and antioxidant effect). P-coumaric acid also acts as a free radical scavenger and inhibits various enzymes, which generate free radicals. It is also used as the raw material for the preparation of preservatives, vanillin, sports foods, skin defense agents, and as a cross-linker for the formation of edible films and food gels. The current study is based upon biological effectiveness, molecular docking, SAR, sources of p-coumaric acid, and related derivatives.
对羟基肉桂酸是一种常见的膳食多酚，以结合态和游离态形式存在于水果、蔬菜和谷物中。该药物的毒性谱非常低，具有多种药理作用（降压、抗炎、抗癌、抗菌活性、抗糖尿病、抗癌和抗氧化作用）。对羟基肉桂酸还可以作为自由基清除剂，抑制产生自由基的各种酶。它还可用作制备防腐剂、香草醛、运动食品、皮肤保护剂以及作为形成可食用膜和食品凝胶的交联剂的原料。本研究基于生物有效性、分子对接、SAR、对羟基肉桂酸的来源和相关衍生物。
