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芥子酸及其衍生物在氧化应激诱导的疾病和衰老中的医学应用。

Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging.

作者信息

Chen Chunye

机构信息

Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.

出版信息

Oxid Med Cell Longev. 2016;2016:3571614. doi: 10.1155/2016/3571614. Epub 2015 Nov 10.

DOI:10.1155/2016/3571614
PMID:27069529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4812465/
Abstract

Sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) is an orally bioavailable phytochemical, extensively found in spices, citrus and berry fruits, vegetables, cereals, and oilseed crops and is known to exhibit antioxidant, anti-inflammatory, anticancer, antimutagenic, antiglycemic, neuroprotective, and antibacterial activities. The literature reveals that sinapic acid is a bioactive phenolic acid and has the potential to attenuate various chemically induced toxicities. This minireview is an effort to summarize the available literature about pharmacokinetic, therapeutic, and protective potential of this versatile molecule in health related areas.

摘要

芥子酸(3,5-二甲氧基-4-羟基肉桂酸)是一种口服生物可利用的植物化学物质,广泛存在于香料、柑橘和浆果、蔬菜、谷物以及油料作物中,已知具有抗氧化、抗炎、抗癌、抗诱变、抗血糖、神经保护和抗菌活性。文献表明,芥子酸是一种生物活性酚酸,具有减轻各种化学诱导毒性的潜力。本综述旨在总结有关这种多功能分子在健康相关领域的药代动力学、治疗和保护潜力的现有文献。

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Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging.芥子酸及其衍生物在氧化应激诱导的疾病和衰老中的医学应用。
Oxid Med Cell Longev. 2016;2016:3571614. doi: 10.1155/2016/3571614. Epub 2015 Nov 10.
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Comparison of the Antihypertensive Activity of Phenolic Acids.比较酚酸的降压活性。
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Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo.阿魏酸通过抗氧化和抗细胞凋亡机制在体外和体内发挥对脑缺血/再灌注损伤的神经保护作用。
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Sinapic acid alleviates renal ischemia-reperfusion injury by regulating oxidative stress, apoptosis, and inflammation.芥子酸通过调节氧化应激、细胞凋亡和炎症来减轻肾脏缺血再灌注损伤。
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Sinapic acid induces cytoplasmic stress granule formation, ER stress and apoptosis mediated anticancer activity in human endometrial cancer cell lines.

本文引用的文献

1
Sinapic Acid and Its Derivatives: Natural Sources and Bioactivity.芥子酸及其衍生物:天然来源与生物活性。
Compr Rev Food Sci Food Saf. 2014 Jan;13(1):34-51. doi: 10.1111/1541-4337.12041.
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4-Hydroxy-3-nitrophenylacetic and Sinapic Acids as Antibacterial Compounds from Mustard Seeds.4-羟基-3-硝基苯乙酸和芥子酸作为芥菜种子中的抗菌化合物。
Biosci Biotechnol Biochem. 1998;62(5):998-1000. doi: 10.1271/bbb.62.998.
3
Antioxidant properties of 4-vinyl derivatives of hydroxycinnamic acids.羟基肉桂酸 4-乙烯基衍生物的抗氧化性能。
芥子酸在人子宫内膜癌细胞系中诱导细胞质应激颗粒形成、内质网应激及凋亡介导的抗癌活性。
Med Oncol. 2025 Jul 18;42(8):345. doi: 10.1007/s12032-025-02926-8.
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Nutrients, Phytochemicals, and In Vitro Antioxidant and Antimicrobial Activities of Lulo ( Lam.) Fruit Pulp, Peel, and Seeds.卢洛(茄科酸浆属)果实果肉、果皮和种子的营养成分、植物化学物质以及体外抗氧化和抗菌活性
Foods. 2025 Jun 13;14(12):2083. doi: 10.3390/foods14122083.
5
Natural Hydroxybenzoic and Hydroxycinnamic Acids Derivatives: Mechanisms of Action and Therapeutic Applications.天然羟基苯甲酸和羟基肉桂酸衍生物:作用机制与治疗应用
Antioxidants (Basel). 2025 Jun 11;14(6):711. doi: 10.3390/antiox14060711.
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Sinapic Acid Ameliorates Cadmium-Induced Hepatotoxicity: Modulation of Oxidative Stress, Inflammation, and Apoptosis.芥子酸改善镉诱导的肝毒性:对氧化应激、炎症和细胞凋亡的调节
Biomedicines. 2025 Apr 28;13(5):1065. doi: 10.3390/biomedicines13051065.
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Cosmeceutical application of extracts from the flowers, stems, and leaves of grown at different altitudes.不同海拔地区种植的[植物名称]花、茎和叶提取物的药妆应用。 注:原文中“grown at different altitudes”前缺少具体植物名称,这里补充了[植物名称]以便译文更完整通顺。你可根据实际情况替换。
Front Pharmacol. 2025 May 9;16:1551134. doi: 10.3389/fphar.2025.1551134. eCollection 2025.
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Unlocking the Health Secrets of Onions: Investigating the Phytochemical Power and Beneficial Properties of Different Varieties and Their Parts.揭开洋葱的健康奥秘:探究不同品种及其部位的植物化学物质力量和有益特性。
Molecules. 2025 Apr 14;30(8):1758. doi: 10.3390/molecules30081758.
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Sinapic Acid Ameliorates Doxorubicin-Induced Cardiotoxicity in H9c2 Cardiomyoblasts by Inhibiting Oxidative Stress Through Activation of the Nrf2 Signaling Pathway.芥子酸通过激活Nrf2信号通路抑制氧化应激,从而改善阿霉素诱导的H9c2心肌成纤维细胞的心脏毒性。
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Natural compounds as therapeutic candidates for spinocerebellar ataxia type 1: a computational approach.天然化合物作为1型脊髓小脑共济失调的治疗候选物:一种计算方法。
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Food Chem. 2011 Sep 1;128(1):62-9. doi: 10.1016/j.foodchem.2011.02.077. Epub 2011 Feb 24.
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Caffeic acid phenethyl ester and therapeutic potentials.咖啡酸苯乙酯及其治疗潜力。
Biomed Res Int. 2014;2014:145342. doi: 10.1155/2014/145342. Epub 2014 May 29.
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Antihyperglycemic action of sinapic acid in diabetic rats.芥子酸对糖尿病大鼠的降血糖作用。
J Agric Food Chem. 2013 Dec 11;61(49):12053-9. doi: 10.1021/jf403092b. Epub 2013 Nov 27.
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Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involves suppression of oxidative stress and inflammatory cytokines.4-乙烯基-2,6-二甲氧基苯酚(坎醇)可预防炎症性肠病和结肠炎相关的癌发生,其作用机制涉及抑制氧化应激和炎症细胞因子。
Carcinogenesis. 2013 Dec;34(12):2833-41. doi: 10.1093/carcin/bgt309. Epub 2013 Sep 24.
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Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats.芥子酸对四氯化碳诱导的大鼠急性肝损伤的影响。
Arch Pharm Res. 2013 May;36(5):626-33. doi: 10.1007/s12272-013-0050-5. Epub 2013 Mar 15.
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A newly synthesized sinapic acid derivative inhibits endothelial activation in vitro and in vivo.一种新合成的芥子酸衍生物可抑制体外和体内的血管内皮细胞激活。
Mol Pharmacol. 2013 May;83(5):1099-108. doi: 10.1124/mol.112.084368. Epub 2013 Mar 7.
9
Effect of sinapic acid against dimethylnitrosamine-induced hepatic fibrosis in rats.芥子酸对二甲基亚硝胺诱导的大鼠肝纤维化的影响。
Arch Pharm Res. 2013 May;36(5):608-18. doi: 10.1007/s12272-013-0033-6. Epub 2013 Feb 23.
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Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats.芥子酸对异丙肾上腺素诱导心肌梗死大鼠心脏肥厚、血脂异常和心电图改变的保护作用。
Eur J Pharmacol. 2013 Jan 15;699(1-3):213-8. doi: 10.1016/j.ejphar.2012.11.012. Epub 2012 Nov 23.