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芥子酸及其衍生物在氧化应激诱导的疾病和衰老中的医学应用。

Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging.

作者信息

Chen Chunye

机构信息

Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.

出版信息

Oxid Med Cell Longev. 2016;2016:3571614. doi: 10.1155/2016/3571614. Epub 2015 Nov 10.

Abstract

Sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) is an orally bioavailable phytochemical, extensively found in spices, citrus and berry fruits, vegetables, cereals, and oilseed crops and is known to exhibit antioxidant, anti-inflammatory, anticancer, antimutagenic, antiglycemic, neuroprotective, and antibacterial activities. The literature reveals that sinapic acid is a bioactive phenolic acid and has the potential to attenuate various chemically induced toxicities. This minireview is an effort to summarize the available literature about pharmacokinetic, therapeutic, and protective potential of this versatile molecule in health related areas.

摘要

芥子酸(3,5-二甲氧基-4-羟基肉桂酸)是一种口服生物可利用的植物化学物质,广泛存在于香料、柑橘和浆果、蔬菜、谷物以及油料作物中,已知具有抗氧化、抗炎、抗癌、抗诱变、抗血糖、神经保护和抗菌活性。文献表明,芥子酸是一种生物活性酚酸,具有减轻各种化学诱导毒性的潜力。本综述旨在总结有关这种多功能分子在健康相关领域的药代动力学、治疗和保护潜力的现有文献。

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