与胰腺炎相关的胰腺外表现：国际调查研究报告。
Extra-pancreatic manifestations reported in association with pancreatitis; an international survey report.
机构信息
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Nebraska Medical Center and Children's Hospital & Medical Center, Omaha, NE, United States of America.
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Alabama at Birmingham, Birmingham, AL, United States of America.
出版信息
PLoS One. 2023 Jul 11;18(7):e0288337. doi: 10.1371/journal.pone.0288337. eCollection 2023.
BACKGROUND/OBJECTIVES: Local and systemic manifestations have been reported in association with pancreatitis, anecdotally. However, a systematic collection on the prevalence of each of these symptoms in pancreatitis is lacking. We aimed to determine the prevalence of symptoms and diagnoses reported by a cohort of patients with pancreatitis, refer to as "extra pancreatic manifestation of pancreatitis".
METHODS
Cross-sectional study approved by the IRB and administered through a REDCap survey by "Mission: Cure", a nonprofit organization.
RESULTS
Of the 225 respondents analyzed; 89% were adults, 69% females, 89% Caucasians with 74% residing in the USA. 42% of children and 50% of adults reported exocrine pancreatic insufficiency while 8% of children and 26% of adults reported DM. Type 3c DM was reported in all children and 45% of adult DM cases. Children were diagnosed with genetic or hereditary pancreatitis more frequently compared to adults (33.3% versus 8%; p = <0.001). Significantly more symptoms and diagnoses were reported by adults when compared to children including nighttime sweats, bloating, or cramping, greasy or oily stools, feeling cold and GERD with p values of 0.002, 0.006, 0.046, 0.002 and 0.003 respectively.
CONCLUSIONS
Adults with pancreatitis frequently report symptoms not known to be associated with pancreatitis. Studies investigating mechanisms for these associated symptoms should be explored.
背景/目的：据报道，胰腺炎可伴有局部和全身表现，但缺乏对胰腺炎中每种症状患病率的系统收集。我们旨在确定胰腺炎患者队列中报告的症状和诊断的患病率，称为“胰腺炎的胰腺外表现”。
方法
这项由 IRB 批准的横断面研究通过非营利组织“使命治愈”（Mission: Cure）的 REDCap 调查进行。
结果
在分析的 225 名受访者中；89%为成年人，69%为女性，89%为白种人，74%居住在美国。42%的儿童和 50%的成年人报告外分泌胰腺功能不全，而 8%的儿童和 26%的成年人报告糖尿病。所有儿童均报告 3 型糖尿病，45%的成年糖尿病患者报告 3 型糖尿病。与成年人相比，儿童更常被诊断为遗传性或遗传性胰腺炎（33.3%比 8%；p<0.001）。与儿童相比，成年人报告了更多的症状和诊断，包括夜间出汗、腹胀或痉挛、油腻或油性粪便、感觉寒冷和 GERD，p 值分别为 0.002、0.006、0.046、0.002 和 0.003。
结论
患有胰腺炎的成年人经常报告与胰腺炎无关的症状。应探索研究这些相关症状的机制。
Zotero 插件