Renner R, Vocke K, Hepp K D
Dtsch Med Wochenschr. 1986 Aug 29;111(35):1316-20. doi: 10.1055/s-2008-1068627.
Porcine and semisynthetic human insulin preparations (Nordisk) having the same content of regular insulin, same galenic characteristics and same degree of purity, were tested in type I, type IIa and type IIb diabetics. There was no difference as to the duration of action. This is contrary to some earlier reports stating that protamine-bound biosynthetic human insulin has a shorter duration of action than porcine preparations. The onset of the hypoglycaemic action in type IIa diabetics is significantly more rapid with isophane human insulin than with isophane pork insulin. The use of an insulin pump prior to testing the duration of action of intermediate insulin preparations appears to be superior to other methods.
对含有相同普通胰岛素含量、相同药剂学特性和相同纯度的猪胰岛素及半合成人胰岛素制剂（诺和诺德公司生产），在I型、IIa型和IIb型糖尿病患者身上进行了测试。在作用持续时间方面没有差异。这与一些早期报告相反，那些报告称鱼精蛋白结合的生物合成人胰岛素的作用持续时间比猪胰岛素制剂短。在IIa型糖尿病患者中，低精蛋白人胰岛素引起低血糖作用的起效时间比低精蛋白猪胰岛素显著更快。在测试中效胰岛素制剂的作用持续时间之前使用胰岛素泵似乎比其他方法更具优势。
