Hu Xingxing, Feng Xiao, Wang Hui, Miao Yudi, Lian Xiaoyun, Gao Qiuying, Gao Ying, Zhai Xinhui, Zhang Ding, Niu Ben, Wang Yi
Department of Hematology, Shaanxi Provincial People's Hospital, Xi'an, China.
Transl Cancer Res. 2023 Jun 30;12(6):1577-1587. doi: 10.21037/tcr-23-503.
In clinical hematology, diffuse large B-cell lymphoma (DLBCL) is notably heterogeneous and varies in prognosis. Serum albumin (SA) is considered a biomarker of prognostic value in a number of hematologic malignancies. However, current knowledge of the association between SA levels and survival is limited, especially in DLBCL patients aged ≥70 years. Thus, this study sought to assess the prognostic value of SA levels among this age group of patients.
The data of DLBCL patients aged ≥70 years at the Shaanxi Provincial People's Hospital in China from 2010 to 2021 were retrospectively reviewed. The SA levels were measured using standard procedures. The Kaplan-Meier method was used to estimate survival time, and the Cox proportional hazards model for time-to-event data was used to identify potential risk factors.
The data of 96 participants were included in the study. The univariate analysis showed that B symptoms, Ann Arbor stage III or IV of the disease, high International Prognostic Index (IPI) scores, high NCCN-IPI scores, and low SA levels were prognostic factors for an undesirable overall survival (OS) rate. The multivariate analysis showed that a high SA level (hazard ratio: 0.43; 95% confidence interval: 0.2-0.88; P=0.022) was an independent prognostic factor of superior outcomes.
An SA level ≥4.0 g/dL was identified as an independent biomarker of prognostic value for DLBCL patients aged ≥70 years.
在临床血液学中，弥漫性大B细胞淋巴瘤（DLBCL）具有显著的异质性，预后也各不相同。血清白蛋白（SA）在多种血液系统恶性肿瘤中被认为是具有预后价值的生物标志物。然而，目前关于SA水平与生存率之间关联的认识有限，尤其是在年龄≥70岁的DLBCL患者中。因此，本研究旨在评估该年龄组患者中SA水平的预后价值。
回顾性分析了2010年至2021年在中国陕西省人民医院年龄≥70岁的DLBCL患者的数据。采用标准程序测量SA水平。使用Kaplan-Meier方法估计生存时间，并使用Cox比例风险模型分析事件发生时间数据以确定潜在风险因素。
96名参与者的数据纳入了本研究。单因素分析显示，B症状、疾病Ann Arbor分期为III期或IV期、国际预后指数（IPI）评分高、NCCN-IPI评分高以及SA水平低是总生存率（OS）不理想的预后因素。多因素分析显示，高SA水平（风险比：0.43；95%置信区间：0.2 - 0.88；P = 0.022）是预后较好的独立预后因素。
SA水平≥4.0 g/dL被确定为年龄≥70岁的DLBCL患者具有预后价值的独立生物标志物。
