黄芩素通过p38丝裂原活化蛋白激酶途径抑制α-黑素细胞刺激素诱导的B16F10小鼠黑色素瘤细胞的黑色素生成。
Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells.
作者信息
Oh Min Chang, Fernando Pincha Devage Sameera Madushan, Piao Mei Jing, Kang Kyoung Ah, Herath Herath Mudiyanselage Udari Lakmini, Hyun Jin Won
机构信息
Department of Biochemistry, Jeju National University College of Medicine, Jeju, Korea.
Jeju Research Center for Natural Medicine, Jeju National University, Jeju, Korea.
出版信息
J Cancer Prev. 2023 Jun 30;28(2):40-46. doi: 10.15430/JCP.2023.28.2.40.
Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis.
过度暴露于中波紫外线（UVB）会通过分泌α-黑素细胞刺激素（α-MSH）导致恶性和非恶性黑色素瘤的发生。我们研究了黄芩素（5,6,7-三羟基黄酮）是否能抑制α-MSH刺激的黑色素生成。黄芩素可预防UVB和α-MSH诱导的黑色素生成，并减弱α-MSH刺激的酪氨酸酶（单酚单加氧酶）活性以及酪氨酸酶和酪氨酸相关蛋白-2的表达。此外，黄芩素通过p38丝裂原活化蛋白激酶信号通路预防黑色素生成和色素沉着。这些发现表明黄芩素是一种可减轻黑色素生成的天然化合物。
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