三叶型磁性微机器人的构建及其用于细胞运输。
Fabrication of three-lobed magnetic microrobots for cell transportation.
机构信息
Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, USA.
出版信息
J Mater Chem B. 2023 Sep 27;11(37):8926-8932. doi: 10.1039/d3tb00613a.
Mobile microrobots have the potential to transform medical treatments based on therapeutic delivery. Specifically, microrobots are promising candidates for cell transportation in cell-based therapies. Despite recent progress in cellular manipulation by microrobots, there is a significant need to design and fabricate microrobots to advance the field further. In this work, we present a facile approach to manufacturing three-lobed microrobots by a bench-top procedure. The microrobots are actuated by a harmless magnetic field which makes them biofriendly. Chemically, these microrobots are made of organosilica. The microrobots showed equally good control in both the open-loop and closed-loop settings. The three-lobed microrobots have two modes of motion during the open-loop control experiments. We employed these two modes for single-cell transportation. Our results show that the three-lobed microbots are very promising for cell transportation in a fluid.
移动微型机器人有可能彻底改变基于治疗药物输送的医疗方法。具体而言，微型机器人是细胞疗法中细胞运输的有前途的候选者。尽管微型机器人在细胞操纵方面最近取得了进展，但仍需要设计和制造微型机器人以进一步推动该领域的发展。在这项工作中，我们提出了一种通过台式程序制造三叶微型机器人的简便方法。微型机器人由无害的磁场驱动，因此对生物无害。从化学角度来看，这些微型机器人是由有机硅制成的。微型机器人在开环和闭环设置下均具有同等良好的控制效果。在开环控制实验中，三叶微型机器人有两种运动模式。我们将这两种模式用于单细胞运输。我们的结果表明，三叶微型机器人在流体中的细胞运输方面非常有前途。
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