Rivas David, Mallick Sudipta, Sokolich Max, Das Sambeeta
Department of Mechanical Engineering, University of Delaware.
Int Conf Manip Autom Robot Small Scales. 2022 Jul;2022. doi: 10.1109/marss55884.2022.9870486. Epub 2022 Sep 2.
Many biomedical applications, such as targeted drug delivery or cell manipulation, are well suited for the deployment of microrobots, untethered devices that are capable of carrying out tasks at the microscale. One biocompatible means of driving microrobots relies on magnetic actuation. In particular, microrobots driven using rotating fields rather than magnetic field gradients are especially practical for real-word applications. Many biological applications involve enclosed environments, such as blood vessels, in which surfaces are abundant, therefore, surface rolling is a particularly pertinent method of transportation. In this paper we demonstrate manipulation and transportation of cells using two types of magnetically driven rolling microrobots. We find that the microrobots are able to manipulate the cells by physically pushing or by first adhering to the cells and then carrying them. Microrobots spinning at high rates also can transport cells via the induced fluid flows.
许多生物医学应用,如靶向药物递送或细胞操控,都非常适合部署微型机器人,即能够在微观尺度上执行任务的无系绳设备。驱动微型机器人的一种生物相容性方法依赖于磁驱动。特别是,使用旋转磁场而非磁场梯度驱动的微型机器人对于实际应用尤为实用。许多生物应用涉及封闭环境,如血管,其中表面丰富,因此,表面滚动是一种特别相关的运输方式。在本文中,我们展示了使用两种类型的磁驱动滚动微型机器人对细胞进行操控和运输。我们发现,微型机器人能够通过物理推动或先附着在细胞上然后携带它们来操控细胞。高速旋转的微型机器人也可以通过诱导的流体流动来运输细胞。
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