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使用滚动微型机器人进行细胞操作。

Cellular Manipulation Using Rolling Microrobots.

作者信息

Rivas David, Mallick Sudipta, Sokolich Max, Das Sambeeta

机构信息

Department of Mechanical Engineering, University of Delaware.

出版信息

Int Conf Manip Autom Robot Small Scales. 2022 Jul;2022. doi: 10.1109/marss55884.2022.9870486. Epub 2022 Sep 2.


DOI:10.1109/marss55884.2022.9870486
PMID:37663239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10474612/
Abstract

Many biomedical applications, such as targeted drug delivery or cell manipulation, are well suited for the deployment of microrobots, untethered devices that are capable of carrying out tasks at the microscale. One biocompatible means of driving microrobots relies on magnetic actuation. In particular, microrobots driven using rotating fields rather than magnetic field gradients are especially practical for real-word applications. Many biological applications involve enclosed environments, such as blood vessels, in which surfaces are abundant, therefore, surface rolling is a particularly pertinent method of transportation. In this paper we demonstrate manipulation and transportation of cells using two types of magnetically driven rolling microrobots. We find that the microrobots are able to manipulate the cells by physically pushing or by first adhering to the cells and then carrying them. Microrobots spinning at high rates also can transport cells via the induced fluid flows.

摘要

许多生物医学应用,如靶向药物递送或细胞操控,都非常适合部署微型机器人,即能够在微观尺度上执行任务的无系绳设备。驱动微型机器人的一种生物相容性方法依赖于磁驱动。特别是,使用旋转磁场而非磁场梯度驱动的微型机器人对于实际应用尤为实用。许多生物应用涉及封闭环境,如血管,其中表面丰富,因此,表面滚动是一种特别相关的运输方式。在本文中,我们展示了使用两种类型的磁驱动滚动微型机器人对细胞进行操控和运输。我们发现,微型机器人能够通过物理推动或先附着在细胞上然后携带它们来操控细胞。高速旋转的微型机器人也可以通过诱导的流体流动来运输细胞。

相似文献

[1]
Cellular Manipulation Using Rolling Microrobots.

Int Conf Manip Autom Robot Small Scales. 2022-7

[2]
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Int Conf Manip Autom Robot Small Scales. 2023-10

[3]
A review on microrobots driven by optical and magnetic fields.

Lab Chip. 2023-3-1

[4]
A Survey of Recent Developments in Magnetic Microrobots for Micro-/Nano-Manipulation.

Micromachines (Basel). 2024-3-29

[5]
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ACS Biomater Sci Eng. 2024-9-9

[6]
Cooperative Micromanipulation Using the Independent Actuation of Fifty Microrobots in Parallel.

Sci Rep. 2017-6-12

[7]
Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery.

Micromachines (Basel). 2019-3-31

[8]
Magnetic Microrobots as a Platform for Cell Clean Up.

Int Conf Manip Autom Robot Small Scales. 2023-10

[9]
Bio-inspired magnetic swimming microrobots for biomedical applications.

Nanoscale. 2013-2-21

[10]
Inductive sensing of magnetic microrobots under actuation by rotating magnetic fields.

PNAS Nexus. 2023-9-12

引用本文的文献

[1]
Magnetic Microrobots as a Platform for Cell Clean Up.

Int Conf Manip Autom Robot Small Scales. 2023-10

[2]
Closed-loop Control for a Heterogeneous Group of Magnetically-actuated Microrobots.

Int Conf Manip Autom Robot Small Scales. 2023-10

[3]
Targeted Vibration-Induced Necrosis in Liver Cancer Cells using Paramagnetic Microrobots.

Int Conf Manip Autom Robot Small Scales. 2023-10

[4]
Learning a Tracking Controller for Rolling bots.

IEEE Robot Autom Lett. 2024-2

[5]
Closed Loop Control of Bubble-Propelled Microrobots.

Int Conf Manip Autom Robot Small Scales. 2023-10

[6]
Rolling Helical Microrobots for Cell Patterning.

Int Conf Manip Autom Robot Small Scales. 2023-10

[7]
Programmable Modular Acoustic Microrobots.

Int Conf Manip Autom Robot Small Scales. 2023-10

[8]
A Review of Single-Cell Microrobots: Classification, Driving Methods and Applications.

Micromachines (Basel). 2023-8-31

[9]
Micro-/nanoscale robotics for chemical and biological sensing.

Lab Chip. 2023-8-22

[10]
ModMag: A modular magnetic micro-robotic manipulation device.

MethodsX. 2023-4-3

本文引用的文献

[1]
Shape anisotropy-governed locomotion of surface microrollers on vessel-like microtopographies against physiological flows.

Proc Natl Acad Sci U S A. 2021-3-30

[2]
Intracellular manipulation and measurement with multipole magnetic tweezers.

Sci Robot. 2019-3-13

[3]
Magnetically actuated microrobots as a platform for stem cell transplantation.

Sci Robot. 2019-5-29

[4]
Multifunctional surface microrollers for targeted cargo delivery in physiological blood flow.

Sci Robot. 2020-5-20

[5]
Single Cell Isolation Using Optical Tweezers.

Micromachines (Basel). 2018-8-29

[6]
Design of Microscale Magnetic Tumbling Robots for Locomotion in Multiple Environments and Complex Terrains.

Micromachines (Basel). 2018-2-3

[7]
Optical manipulation from the microscale to the nanoscale: fundamentals, advances and prospects.

Light Sci Appl. 2017-9-22

[8]
Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity.

Toxicol Sci. 2018-7-1

[9]
Magnetically Actuated Peanut Colloid Motors for Cell Manipulation and Patterning.

ACS Nano. 2018-2-16

[10]
Biomedical Applications of Untethered Mobile Milli/Microrobots.

Proc IEEE Inst Electr Electron Eng. 2015-2

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