Dai Yuguo, Jia Lina, Wang Luyao, Sun Hongyan, Ji Yiming, Wang Chutian, Song Li, Liang Shuzhang, Chen Dixiao, Feng Yanmin, Bai Xue, Zhang Deyuan, Arai Fumihito, Chen Huawei, Feng Lin
School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
Department of Mechanical Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
Small. 2022 Apr;18(15):e2105414. doi: 10.1002/smll.202105414. Epub 2022 Mar 1.
Border-nearing microrobots with self-propelling and navigating capabilities have promising applications in micromanipulation and bioengineering, because they can stimulate the surrounding fluid flow for object transportation. However, ensuring the biosafety of microrobots is a concurrent challenge in bioengineering applications. Here, macrophage template-based microrobots (cell robots) that can be controlled individually or in chain-like swarms are proposed, which can transport various objects. The cell robots are constructed using the phagocytic ability of macrophages to load nanomagnetic particles while maintaining their viability. The robots exhibit high position control accuracy and generate a flow field that can be used to transport microspheres and sperm when exposed to an external magnetic field near a wall. The cell robots can also form chain-like swarms to transport a large object (more than 100 times the volume). This new insight into the manipulation of macrophage-based cell robots provides a new concept by converting other biological cells into microrobots for micromanipulation in biomedical applications.
具有自推进和导航能力的近边界微型机器人在微操纵和生物工程领域有着广阔的应用前景，因为它们可以刺激周围流体流动以实现物体运输。然而，确保微型机器人的生物安全性是生物工程应用中同时面临的一项挑战。在此，提出了基于巨噬细胞模板的微型机器人（细胞机器人），它们可以单独控制或形成链状群体，能够运输各种物体。这些细胞机器人利用巨噬细胞的吞噬能力构建，在保持其活力的同时加载纳米磁性颗粒。当在靠近壁的外部磁场作用下，这些机器人表现出较高的位置控制精度，并产生可用于运输微球和精子的流场。细胞机器人还可以形成链状群体来运输大型物体（体积超过100倍）。这种对基于巨噬细胞的细胞机器人操纵的新见解通过将其他生物细胞转化为微型机器人，为生物医学应用中的微操纵提供了一个新概念。
