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大肠杆菌K-12的sbc-A菌株中紫外线损伤的脱氧核糖核酸的修复

Repair of ultraviolet light-damaged deoxyribonucleic acid in sbc-A strains of Escherichia coli K-12.

作者信息

Shlaes D M, Barbour S D

出版信息

J Bacteriol. 1979 Apr;138(1):105-8. doi: 10.1128/jb.138.1.105-108.1979.

DOI:10.1128/jb.138.1.105-108.1979
PMID:374357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218244/
Abstract

An Escherichia coli strain carrying both rec+ and sbcA has been constructed. Repair of ultraviolet light-induced deoxyribonucleic acid damage was examined by measuring survival and thymine-dimer excision in the rec+ sbcA strain as well as rec+ sbcA+ and recB recC sbcA strains. The sbcA mutation restores normal survival in both recB recC uvrB and recB recC uvr+ strains. Excision of thymine-containing dimers does not occur in uvrB mutants, regardless of the rec or sbcA genotype. Survival, after ultraviolet-light damage, of a rec+ sbcA strain is quantitatively similar to rec+ sbcA+ and recB recC sbcA strains.

摘要

构建了一株同时携带rec⁺和sbcA的大肠杆菌菌株。通过测量rec⁺ sbcA菌株以及rec⁺ sbcA⁺和recB recC sbcA菌株的存活率和胸腺嘧啶二聚体切除情况，来检测紫外线诱导的脱氧核糖核酸损伤的修复。sbcA突变可恢复recB recC uvrB和recB recC uvr⁺菌株的正常存活率。无论rec或sbcA基因型如何，uvrB突变体中均不会发生含胸腺嘧啶二聚体的切除。rec⁺ sbcA菌株在紫外线损伤后的存活率在数量上与rec⁺ sbcA⁺和recB recC sbcA菌株相似。

相似文献

1
Repair of ultraviolet light-damaged deoxyribonucleic acid in sbc-A strains of Escherichia coli K-12.大肠杆菌K-12的sbc-A菌株中紫外线损伤的脱氧核糖核酸的修复
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2
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Repair of cross-linked DNA and survival of Escherichia coli treated with psoralen and light: effects of mutations influencing genetic recombination and DNA metabolism.补骨脂素与光照处理后大肠杆菌交联DNA的修复及存活：影响基因重组和DNA代谢的突变的作用
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Pyrimidine dimer excision in Escherichia coli strains deficient in exonucleases V and VII and in the 5' leads to 3' exonuclease of DNA polymerase I.在缺乏核酸外切酶V和VII以及DNA聚合酶I的5'至3'核酸外切酶活性的大肠杆菌菌株中嘧啶二聚体的切除。
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本文引用的文献

1
Mutants of Escherichia coli K-12 defective in DNA repair and in genetic recombination.大肠杆菌K-12中DNA修复和基因重组存在缺陷的突变体。
Genetics. 1966 Jun;53(6):1137-50. doi: 10.1093/genetics/53.6.1137.
2
DNA repair and genetic recombination: studies on mutants of Escherichia coli defective in these processes.DNA修复与基因重组：对在这些过程中存在缺陷的大肠杆菌突变体的研究。
Radiat Res. 1966:Suppl 6:156+.
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Involvement of recombination genes in growth and viability of Escherichia coli K-12.重组基因与大肠杆菌K-12生长及生存能力的关系。
J Bacteriol. 1971 Apr;106(1):204-12. doi: 10.1128/jb.106.1.204-212.1971.
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Genetic recombination in Escherichia coli: the role of exonuclease I.大肠杆菌中的基因重组：核酸外切酶I的作用。
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Repair of radiation-induced damage in Escherichia coli. I. Effect of rec mutations on post-replication repair of damage due to ultraviolet radiation.大肠杆菌中辐射诱导损伤的修复。I. rec突变对紫外线辐射所致损伤的复制后修复的影响。
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6
An ATP-dependent deoxyribonuclease from Escherichia coli with a possible role in genetic recombination.一种来自大肠杆菌的依赖ATP的脱氧核糖核酸酶，可能在基因重组中发挥作用。
Proc Natl Acad Sci U S A. 1969 Dec;64(4):1292-9. doi: 10.1073/pnas.64.4.1292.
7
Repair of radiation-induced damage in Escherichia coli. II. Effect of rec and uvr mutations on radiosensitivity, and repair of x-ray-induced single-strand breaks in deoxyribonucleic acid.大肠杆菌中辐射诱导损伤的修复。II. rec和uvr突变对辐射敏感性的影响，以及脱氧核糖核酸中X射线诱导的单链断裂的修复
J Bacteriol. 1970 Jul;103(1):49-54. doi: 10.1128/jb.103.1.49-54.1970.
8
Biochemical and genetic studies of recombination proficiency in Escherichia coli. I. Enzymatic activity associated with recB+ and recC+ genes.大肠杆菌中重组能力的生化与遗传学研究。I. 与recB+和recC+基因相关的酶活性。
Proc Natl Acad Sci U S A. 1970 Apr;65(4):955-61. doi: 10.1073/pnas.65.4.955.
9
Genetic analysis of recombination-deficient mutants of Escherichia coli K-12 carrying rec mutations cotransducible with thyA.携带与thyA共转导的rec突变的大肠杆菌K-12重组缺陷型突变体的遗传分析。
J Bacteriol. 1969 Nov;100(2):923-34. doi: 10.1128/jb.100.2.923-934.1969.
10
Characteristics of some multiply recombination-deficient strains of Escherichia coli.一些多重重组缺陷型大肠杆菌菌株的特征
J Bacteriol. 1969 Oct;100(1):231-9. doi: 10.1128/jb.100.1.231-239.1969.