Gozariu L, Stroe M, Vladutiu T, Yepez-Escobar N G, Simionescu L, Szantay I, Dumitru E, Florescu O
Exp Clin Endocrinol. 1986 Jun;87(1):48-52. doi: 10.1055/s-0029-1210522.
The authors followed up the incidence of permanent hypothyroidism in 35 patients with subacute thyroiditis (SAT) in their past history. The investigations were made one to four years after the acute episode. Ten of these presented repeated recurrences despite the therapy with glucocorticoids. The investigations included serum determination by RIA of T4, T3, TSH and thyroglobulin as well as of circulating thyroid antibodies. Permanent hypothyroidism subsequent to SAT occurred in two patients. In one of them it occurred following thyroid surgery performed for repeated recurrences. Both patients presented high levels of circulating thyroglobulin antibodies suggesting a possible transition to autoimmune thyroiditis. In the authors' opinion permanent hypothyroidism is likely to develop after SAT only in association with an autoimmune process or after thyroid surgery.
作者对35例有亚急性甲状腺炎（SAT）病史患者的永久性甲状腺功能减退症发病率进行了随访。在急性发作后的1至4年进行了调查。其中10例患者尽管接受了糖皮质激素治疗仍反复复发。调查包括通过放射免疫分析（RIA）测定血清中的T4、T3、促甲状腺激素（TSH）、甲状腺球蛋白以及循环甲状腺抗体。SAT后发生永久性甲状腺功能减退症的有2例患者。其中1例是在因反复复发而进行甲状腺手术后发生的。两名患者循环甲状腺球蛋白抗体水平均较高，提示可能转变为自身免疫性甲状腺炎。作者认为，SAT后永久性甲状腺功能减退症仅在与自身免疫过程相关或甲状腺手术后才可能发生。
