Hnilica P, Nyulassy S
Endocrinol Exp. 1985 Dec;19(4):221-6.
The occurrence of permanent overt hypothyroidism (POH) following subacute thyroiditis (SAT) was studied in 103 patients during 11-142 months (mean 52.8 months). Increased amount of plasma cells in cytological pictures of goitre aspirates was found at the time of diagnosis of SAT in 25 cases (24.3%). POH developed in 11 patients (10.7%). Eight patients with high titres of circulating thyroid antibodies demonstrated also cytological characteristics of autoimmune thyroiditis (increased amount of plasma cells inclusively) at the time of the diagnosis of SAT. Early developing POH in these patients was found. The association with HLA-Bw35 in this subgroup was not striking. In another subgroup of 3 patients POH developed after an interval of several years of euthyroidism following SAT. In such cases the autoimmune thyroiditis was not conspicuous and HLA-Bw35 was found in all 3 cases. Increased amount of plasma cells in aspirates of goitre at the time of symptomatology of SAT was observed only in one patient. It is concluded that increased amount of plasma cells (in addition to usual cytological picture of SAT) in aspirates of goitre at the time of clinical manifestation of SAT may be a warning of increased risk of development of permanent hypothyroidism following SAT. Some speculations on possible heterogeneity of subacute thyroiditis are presented.
对103例患者在11至142个月（平均52.8个月）期间发生的亚急性甲状腺炎（SAT）后永久性显性甲状腺功能减退（POH）进行了研究。在SAT诊断时，25例（24.3%）甲状腺肿穿刺物细胞学图片中浆细胞数量增加。11例患者（10.7%）发生了POH。8例循环甲状腺抗体滴度高的患者在SAT诊断时也表现出自身免疫性甲状腺炎的细胞学特征（包括浆细胞数量增加）。在这些患者中发现了早期发生的POH。该亚组中与HLA - Bw35的关联并不显著。在另一个由3例患者组成的亚组中，POH在SAT后数年的甲状腺功能正常期后发生。在这种情况下，自身免疫性甲状腺炎并不明显，3例患者均发现有HLA - Bw35。仅1例患者在SAT症状出现时甲状腺肿穿刺物中浆细胞数量增加。结论是，在SAT临床表现时甲状腺肿穿刺物中浆细胞数量增加（除了SAT通常的细胞学表现外）可能是SAT后永久性甲状腺功能减退发生风险增加的一个警示。文中还对亚急性甲状腺炎可能的异质性提出了一些推测。
