Tikkanen M J, Lamberg B A
Acta Endocrinol (Copenh). 1982 Nov;101(3):348-53. doi: 10.1530/acta.0.1010348.
The occurrence of permanent overt or subclinical hypothyroidism following subacute thyroiditis (SAT) was studied in 32 patients during 0.75-13 years (mean 4.2 years) of follow-up. Permanent hypothyroidism developed in 2 patients in whom a characteristic feature was persistent of circulating thyroid antibodies in high titres from the onset of SAT indicating the presence of autoimmune thyroiditis. One also showed cytological evidence of autoimmune thyroiditis. In another patient subclinical hypothyroidism demonstrated by an exaggerated TSH-response to TRH, persisted after hemithyroidectomy during the acute phase. In addition, transient overt hyperthyroidism developed immediately after the acute phase in 3, and subclinical hypothyroidism in 2 patients. Apart from the 2 patients with evidence of autoimmune thyroiditis, circulating thyroid antibodies were found in 15 others. The titres were usually low and disappeared in most cases after a transient rise. It is concluded that permanent hypothyroidism is likely to develop after SAT only in the presence of autoimmune thyroiditis or after thyroid surgery.
对32例亚急性甲状腺炎（SAT）患者进行了0.75至13年（平均4.2年）的随访，研究SAT后永久性显性或亚临床甲状腺功能减退的发生情况。2例患者发生了永久性甲状腺功能减退，其特征是从SAT发病开始循环甲状腺抗体持续高滴度存在，提示自身免疫性甲状腺炎的存在。其中1例还显示出自身免疫性甲状腺炎的细胞学证据。另1例患者在急性期行半甲状腺切除术后，对促甲状腺激素释放激素（TRH）的促甲状腺激素反应增强所显示的亚临床甲状腺功能减退持续存在。此外，3例患者在急性期后立即出现短暂性显性甲状腺功能亢进，2例出现亚临床甲状腺功能减退。除了2例有自身免疫性甲状腺炎证据的患者外，另外15例患者发现有循环甲状腺抗体。其滴度通常较低，大多数情况下在短暂升高后消失。结论是，仅在存在自身免疫性甲状腺炎或甲状腺手术后，SAT后才可能发生永久性甲状腺功能减退。
