基于模式化感觉增强的训练对改善帕金森病患者上肢运动的效果：一项随机对照试验方案。
Effects of training involving patterned sensory enhancement on improving upper-limb movements in patients with Parkinson's disease: protocol of a randomised controlled trial.
机构信息
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China
出版信息
BMJ Open. 2023 Jul 12;13(7):e072416. doi: 10.1136/bmjopen-2023-072416.
INTRODUCTION
Bradykinesia (ie, slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life. Rhythmic auditory stimulation (RAS), a widely used and promising treatment technique, has been shown to effectively improve gait speed in patients with PD. The upper-limb movements, which also suffer from bradykinesia, are essential for daily life and directly impact quality of life. The term, patterned sensory enhancement (PSE) instead of RAS, is used when movement training targets the human body except lower limbs. Up until now, scarce studies have explored effects of training involving PSE on upper-limb movements. The purpose of this study is to investigate effects of movement training involving PSE on upper-limb movement speed and function in patients with PD.
METHODS AND ANALYSIS
A total of 138 patients with PD will be randomly assigned into two groups: the PSE group and the no-PSE group. A 21-day upper-limb training involving PSE (for the PSE group) or without PSE (for the no-PSE group) will be provided to the patients. An assessor will administer the box and block test and the Jebsen hand function test before and after training to assess upper-limb movement speed and function. The one-way analysis of covariance will be performed. This randomised controlled trial will provide evidence supporting effectiveness of upper-limb movement training involving PSE on reducing severity of bradykinesia in patients with PD.
ETHICS AND DISSEMINATION
Ethical approval has been obtained from the Institutional Review Board of the Hong Kong Polytechnic University with the reference number HSEARS20221027005. Informed consent forms will be gathered from all patients before their participation. Study results will be disseminated through conferences and peer-reviewed academic journals.
TRIAL REGISTRATION NUMBER
NCT05637593.
简介
运动徐缓（即动作缓慢）是帕金森病（PD）最显著的症状之一，对生活质量有负面影响。节律性听觉刺激（RAS）是一种广泛应用且有前途的治疗技术，已被证明可有效提高 PD 患者的步行速度。上肢运动也受到运动徐缓的影响，对日常生活至关重要，直接影响生活质量。当运动训练的目标是除下肢以外的人体时，术语“模式化感觉增强（PSE）”而非 RAS 被使用。到目前为止，很少有研究探讨涉及 PSE 的训练对上肢运动的影响。本研究旨在探讨涉及 PSE 的运动训练对上肢运动速度和功能的影响。
方法和分析
共有 138 名 PD 患者将被随机分为两组：PSE 组和无 PSE 组。将为患者提供为期 21 天的涉及 PSE 的上肢训练（PSE 组）或不涉及 PSE 的上肢训练（无 PSE 组）。训练前后，评估员将进行盒-块测试和 Jebsen 手功能测试，以评估上肢运动速度和功能。将进行单因素方差分析。这项随机对照试验将为涉及 PSE 的上肢运动训练可减轻 PD 患者运动徐缓严重程度的有效性提供证据。
伦理和传播
香港理工大学机构审查委员会已批准该研究，参考编号为 HSEARS20221027005。在患者参与之前，将从所有患者那里收集知情同意书。研究结果将通过会议和同行评审的学术期刊进行传播。
试验注册号
NCT05637593。
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