Department of Psychology and Program in Molecular, Cellular, and Integrative Neurosciences, Colorado State University, Fort Collins, CO, 80523, USA.
Department of Experimental Psychology, University College London, London, UK.
Eur J Neurosci. 2019 Mar;49(6):849-858. doi: 10.1111/ejn.14227. Epub 2018 Dec 3.
It is well established clinically that rhythmic auditory cues can improve gait and other motor behaviors in Parkinson's disease (PD) and other disorders. However, the neural systems underlying this therapeutic effect are largely unknown. To investigate this question we scanned people with PD and age-matched healthy controls using functional magnetic resonance imaging (fMRI). All subjects performed a rhythmic motor behavior (right hand finger tapping) with and without simultaneous auditory rhythmic cues at two different speeds (1 and 4 Hz). We used spatial independent component analysis (ICA) and regression to identify task-related functional connectivity networks and assessed differences between groups in intra- and inter-network connectivity. Overall, the control group showed greater intra-network connectivity in perceptual and motor related networks during motor tapping both with and without rhythmic cues. The PD group showed greater inter-network connectivity between the auditory network and the executive control network, and between the executive control network and the motor/cerebellar network associated with the motor task performance. We interpret our results as indicating that the temporal rhythmic auditory information may assist compensatory mechanisms through network-level effects, reflected in increased interaction between auditory and executive networks that in turn modulate activity in cortico-cerebellar networks.
临床研究已经证实，节奏性听觉提示可以改善帕金森病（PD）和其他疾病的步态和其他运动行为。然而，这种治疗效果的神经机制在很大程度上尚不清楚。为了研究这个问题，我们使用功能磁共振成像（fMRI）对 PD 患者和年龄匹配的健康对照组进行了扫描。所有受试者都进行了节奏性运动行为（右手手指敲击），同时伴有和不伴有两种不同速度（1Hz 和 4Hz）的节奏性听觉提示。我们使用空间独立成分分析（ICA）和回归来识别与任务相关的功能连接网络，并评估组间的网络内和网络间连接的差异。总的来说，在进行运动敲击时，对照组在有节奏和无节奏提示的情况下，在感知和运动相关网络中表现出更大的网络内连接。PD 组在听觉网络和执行控制网络之间，以及在与运动任务表现相关的执行控制网络和运动/小脑网络之间表现出更大的网络间连接。我们的结果表明，时间节奏性听觉信息可能通过网络水平的影响来辅助补偿机制，这反映在听觉和执行网络之间的相互作用增加，进而调节皮质-小脑网络的活动。
