Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China.
BMC Oral Health. 2023 Jul 12;23(1):476. doi: 10.1186/s12903-023-03118-4.
This study aimed to investigate the clinical effects of recombinant human interleukin-11 (rhIL-11) gargle on preventing and treating oral mucositis (OM) after chemotherapy for acute leukemia.
This single-site, prospective, observer-blinded, nonrandomized controlled trial was conducted on 74 patients with acute leukemia, who were divided into the experimental and control groups. The patients in the experimental group were treated with IL-11 gargle, and those in the control group were treated with sodium bicarbonate gargle. We examined the time and severity of oral mucositis, severity and duration of associated pain, healing time of mucositis, effects of OM on eating, and levels of T-cell subset indicators before and after treatment to evaluate the effects of IL-11 treatment.
The proportion of patients with severe OM was significantly lower in the experimental group than in the control group. Mucositis occurred later in the experimental group compared with the control group. The degree and duration of pain, ulcer healing time, and effects on eating were lower in the experimental group compared with the control group. Following treatment, the levels of all T-cell subset indicators improved in each of the two groups. However, the rate of improvement was significantly higher in the experimental group than in the control group. These differences were statistically significant (P < 0.05).
IL-11 gargle reduced the severity of OM after chemotherapy for acute leukemia. Treatment with IL-11 relieved pain, promoted healing, and improved the curative effect of the condition, making it worthy of clinical promotion.
本研究旨在探讨重组人白细胞介素-11（rhIL-11）含漱液预防和治疗急性白血病化疗后口腔黏膜炎（OM）的临床效果。
采用单中心、前瞻性、观察者设盲、非随机对照试验，纳入 74 例急性白血病患者，分为实验组和对照组。实验组采用 rhIL-11 含漱液治疗，对照组采用碳酸氢钠含漱液治疗。通过观察口腔黏膜炎的发生时间和严重程度、相关疼痛的严重程度和持续时间、黏膜炎愈合时间、OM 对进食的影响以及治疗前后 T 细胞亚群指标的变化，评估 rhIL-11 治疗的效果。
实验组重度 OM 的比例显著低于对照组。实验组 OM 发生时间晚于对照组。实验组疼痛程度和持续时间、溃疡愈合时间和对进食的影响均低于对照组。两组治疗后 T 细胞亚群指标水平均有所改善，但实验组的改善率明显高于对照组，差异有统计学意义（P<0.05）。
rhIL-11 含漱液可减轻急性白血病化疗后 OM 的严重程度。rhIL-11 治疗可缓解疼痛，促进愈合，提高疗效，值得临床推广。
