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加强针接种和奥密克戎：对荷兰献血者体内 SARS-CoV-2 抗体的影响。

Booster vaccinations and Omicron: the effects on SARS-CoV-2 antibodies in Dutch blood donors.

机构信息

Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands.

Department of Virology, Sanquin Diagnostic Services, Amsterdam, the Netherlands.

出版信息

BMC Infect Dis. 2023 Jul 12;23(1):464. doi: 10.1186/s12879-023-08448-w.

DOI:10.1186/s12879-023-08448-w
PMID:37438703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10339593/
Abstract

INTRODUCTION

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) booster vaccination campaign and the emergence of SARS-CoV-2 Omicron variants impact the prevalence and levels of SARS-CoV-2 antibodies in the Netherlands. In this study we determined antibody levels across age groups, the impact of Omicron variant infections, and the effect of booster vaccinations on antibody levels.

METHODS

In September and December 2021 and in February 2022, over 2000 Dutch blood donors were tested for presence of SARS-CoV-2 antibodies. Donations were selected based on age, sex, and region of residence, to provide an optimal coverage and representation of the Dutch population.

RESULTS

Levels of vaccination-induced spike antibodies decreased over time in all age groups. Donors vaccinated with Janssen or AstraZeneca had significantly lower antibody levels than donors vaccinated with Pfizer or Moderna vaccine. Boostering with an mRNA vaccine elevated antibody levels in all age-groups irrespective of the initial vaccine. In donors aged < 56 years, the proportion of infected donors almost doubled between December 2021 and February 2022.

CONCLUSION

The booster vaccination campaign increased antibody levels in all age-groups. After a booster vaccination, donors initially vaccinated with AstraZeneca or Janssen vaccine showed antibody levels similar to donors initially vaccinated with an mRNA vaccine. The emergence of the SARS-CoV-2 Omicron variant in the Netherlands caused a substantial increase in donors with infection-induced antibodies, especially among younger donors.

摘要

简介

严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）加强针接种运动和 SARS-CoV-2 奥密克戎变异株的出现，影响了荷兰 SARS-CoV-2 抗体的流行率和水平。在这项研究中，我们确定了各年龄段的抗体水平、奥密克戎变异株感染的影响，以及加强针接种对抗体水平的影响。

方法

在 2021 年 9 月、12 月和 2022 年 2 月，对 2000 多名荷兰献血者进行了 SARS-CoV-2 抗体检测。根据年龄、性别和居住地区域选择献血者，以提供荷兰人口的最佳覆盖和代表性。

结果

所有年龄段的疫苗诱导刺突抗体水平随时间推移而下降。接种 Janssen 或阿斯利康疫苗的献血者的抗体水平明显低于接种辉瑞或 Moderna 疫苗的献血者。所有年龄段的 mRNA 疫苗加强针都提高了抗体水平，无论初始疫苗如何。在<56 岁的献血者中，2021 年 12 月至 2022 年 2 月期间，感染献血者的比例几乎翻了一番。

结论

加强针接种运动提高了所有年龄段的抗体水平。在加强针接种后，最初接种阿斯利康或 Janssen 疫苗的献血者的抗体水平与最初接种 mRNA 疫苗的献血者相似。SARS-CoV-2 奥密克戎变异株在荷兰的出现导致感染诱导抗体的献血者大量增加，尤其是在年轻献血者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/c72aceacbbc0/12879_2023_8448_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/acfba9ceb87c/12879_2023_8448_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/26dfcba79963/12879_2023_8448_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/f3b537a7eebe/12879_2023_8448_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/c72aceacbbc0/12879_2023_8448_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/acfba9ceb87c/12879_2023_8448_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/26dfcba79963/12879_2023_8448_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/f3b537a7eebe/12879_2023_8448_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1498/10339593/c72aceacbbc0/12879_2023_8448_Fig4_HTML.jpg

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