Campman Sophie L, Boyd Anders, Schinkel Janke, Coyer Liza, Agyemang Charles, Galenkamp Henrike, Koopman Anitra D M, Chilunga Felix P, Koopsen Jelle, Zwinderman Aeilko H, Jurriaans Suzanne, Stronks Karien, Prins Maria
Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.
Amsterdam UMC location University of Amsterdam, Infectious Diseases, Amsterdam, The Netherlands.
Epidemiol Infect. 2025 Jan 23;153:e23. doi: 10.1017/S0950268825000056.
We studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination status among six ethnic groups in Amsterdam, the Netherlands. We analysed participants of the Healthy Life in an Urban Setting cohort who were tested for SARS-CoV-2 spike protein antibodies between 17 May and 21 November 2022. We categorized participants with antibodies as only infected, only vaccinated (≥1 dose), or both infected and vaccinated, based on self-reported prior infection and vaccination status and previous seroprevalence data. We compared infection and vaccination status between ethnic groups using multivariable, multinomial logistic regression. Of the 1,482 included participants, 98.5% had SARS-CoV-2 antibodies ( between ethnic groups = 0.899). Being previously infected and vaccinated ranged from 41.5% (95% confidence interval (CI) = 35.0-47.9%) in the African Surinamese to 67.1% (95% CI = 59.1-75.0%) in the Turkish group. Compared to participants of Dutch origin, participants of South-Asian Surinamese (adjusted odds ratio (aOR) = 3.31, 95% CI = 1.50-7.31)), African Surinamese (aOR = 10.41, 95% CI = 5.17-20.94), Turkish (aOR = 3.74, 95% CI = 1.52-9.20), or Moroccan (aOR = 15.24, 95% CI = 6.70-34.65) origin were more likely to be only infected than infected and vaccinated, after adjusting for age, sex, household size, trust in the government's response to the pandemic, and month of study visit. SARS-CoV-2 infection and vaccination status varied across ethnic groups, particularly regarding non-vaccination. As hybrid immunity is most protective against coronavirus disease 2019, future vaccination campaigns should encourage vaccination uptake in specific demographic groups with only infection.
我们研究了荷兰阿姆斯特丹六个种族群体中严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的感染情况和疫苗接种状况。我们分析了“城市环境中的健康生活”队列研究的参与者，这些参与者在2022年5月17日至11月21日期间接受了SARS-CoV-2刺突蛋白抗体检测。根据自我报告的既往感染和疫苗接种状况以及先前的血清流行率数据，我们将有抗体的参与者分为仅感染、仅接种疫苗（≥1剂）或既感染又接种疫苗三类。我们使用多变量多项逻辑回归比较了不同种族群体之间的感染和疫苗接种状况。在纳入研究的1482名参与者中，98.5%拥有SARS-CoV-2抗体（种族群体间的P值 = 0.899）。既往既感染又接种疫苗的比例在非洲苏里南人群体中为41.5%（95%置信区间（CI）= 35.0 - 47.9%），在土耳其人群体中为67.1%（95% CI = 59.1 - 75.0%）。在调整了年龄、性别、家庭规模、对政府应对疫情措施的信任度以及研究访视月份后，与荷兰裔参与者相比，南亚苏里南人（调整后的优势比（aOR）= 3.31，95% CI = 1.50 - 7.31）、非洲苏里南人（aOR = 10.41，95% CI = 5.17 - 20.94）、土耳其人（aOR = 3.74，95% CI = 1.52 - 9.20）或摩洛哥人（aOR = 15.24，95% CI = 6.70 - 34.65）更有可能仅感染而未既感染又接种疫苗。SARS-CoV-2的感染和疫苗接种状况在不同种族群体中存在差异，尤其是在未接种疫苗方面。由于混合免疫对2019冠状病毒病的保护作用最强，未来的疫苗接种运动应鼓励仅感染的特定人群接种疫苗。
