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1
Inhibition by itaconate of growth of methylotrophic bacteria.衣康酸对甲基营养型细菌生长的抑制作用。
J Bacteriol. 1979 May;138(2):519-22. doi: 10.1128/jb.138.2.519-522.1979.
2
Itaconate, an isocitrate lyase-directed inhibitor in Pseudomonas indigofera.衣康酸，一种在产靛假单胞菌中由异柠檬酸裂解酶导向的抑制剂。
J Bacteriol. 1977 Jul;131(1):136-44. doi: 10.1128/jb.131.1.136-144.1977.
3
Taurine catabolism. III. Evidence for the participation of the glyoxylate cycle.牛磺酸分解代谢。III. 乙醛酸循环参与的证据。
Biochim Biophys Acta. 1980 Oct 15;632(3):399-407. doi: 10.1016/0304-4165(80)90235-4.
4
Catabolite repression of isocitrate lyase in methylamine-grown Pseudomonas MA. Effect of carbon and nitrogen sources.甲胺培养的假单胞菌MA中异柠檬酸裂解酶的分解代谢物阻遏。碳源和氮源的影响。
Biochim Biophys Acta. 1978 Jul 17;541(4):425-34. doi: 10.1016/0304-4165(78)90152-6.
5
Inhibition of acetate and propionate assimilation by itaconate via propionyl-CoA carboxylase in isocitrate lyase-negative purple bacterium Rhodospirillum rubrum.衣康酸通过丙酰辅酶A羧化酶抑制异柠檬酸裂解酶阴性紫色细菌红螺菌中乙酸和丙酸的同化作用。
FEMS Microbiol Lett. 2002 Oct 29;216(1):49-54. doi: 10.1111/j.1574-6968.2002.tb11413.x.
6
Methylamine metabolism in a pseudomonas species.假单胞菌属中甲基胺的代谢
Arch Biochem Biophys. 1972 Nov;153(1):368-74. doi: 10.1016/0003-9861(72)90457-2.
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Can J Microbiol. 1976 Mar;22(3):404-8. doi: 10.1139/m76-061.
8
Enzymes involved in the assimilation of one-carbon units by Pseudomonas MS.铜绿假单胞菌MS中参与一碳单位同化的酶。
J Bacteriol. 1975 Jun;122(3):905-10. doi: 10.1128/jb.122.3.905-910.1975.
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Caenorhabditis elegans and Ascaris suum: inhibition of isocitrate lyase by itaconate.
Exp Parasitol. 1978 Apr;44(2):262-8. doi: 10.1016/0014-4894(78)90107-8.
10
Isocitrate lyase and malate synthase in Pseudomonas indigofera. I. Suppression and stimulation during growth.产靛假单胞菌中的异柠檬酸裂合酶和苹果酸合酶。I. 生长过程中的抑制和刺激作用
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Designing and Engineering AM1 for Itaconic Acid Production.用于生产衣康酸的AM1的设计与工程
Front Microbiol. 2019 May 9;10:1027. doi: 10.3389/fmicb.2019.01027. eCollection 2019.
2
Glyoxylate bypass enzymes in Yersinia species and multiple forms of isocitrate lyase in Yersinia pestis.耶尔森氏菌属中的乙醛酸旁路酶及鼠疫耶尔森氏菌中的多种形式异柠檬酸裂解酶。
J Bacteriol. 1981 Jan;145(1):452-8. doi: 10.1128/jb.145.1.452-458.1981.

本文引用的文献

1
Microbial growth on C(1) compounds. 5. Enzyme activities in extracts of Pseudomonas AM1.C(1) 化合物上的微生物生长。5. 假单胞菌AM1提取物中的酶活性。
Biochem J. 1963 May;87(2):386-96. doi: 10.1042/bj0870386.
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The assay of insulin solutions by paper chromatography.用纸上色谱法测定胰岛素溶液
Biochem J. 1961 Dec;81(3):570-5. doi: 10.1042/bj0810570.
3
The enzymatic synthesis of N-methylglutamic acid.N-甲基谷氨酸的酶促合成
J Biol Chem. 1966 Feb 25;241(4):935-45.
4
Mechanism of action of isocitrate lyase from Pseudomonas indigofera.产靛假单胞菌异柠檬酸裂合酶的作用机制。
Biochemistry. 1971 Apr 13;10(8):1384-90. doi: 10.1021/bi00784a017.
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Microbial metabolism of C 1 and C 2 compounds. The involvement of glycollate in the metabolism of ethanol and of acetate by Pseudomonas AM1.C1和C2化合物的微生物代谢。乙醇酸在假单胞菌AM1对乙醇和乙酸盐代谢中的作用。
Biochem J. 1972 Jun;128(1):99-106. doi: 10.1042/bj1280099.
6
Cleavage of malyl-Coenzyme A into acetyl-Coenzyme A and glyoxylate by Pseudomonas AM1 and other C1-unit-utilizing bacteria.假单胞菌AM1及其他利用C1单位的细菌将苹果酰辅酶A裂解为乙酰辅酶A和乙醛酸。
Biochem J. 1973 Sep;136(1):89-96. doi: 10.1042/bj1360089.
7
Methylamine metabolism in a pseudomonas species.假单胞菌属中甲基胺的代谢
Arch Biochem Biophys. 1972 Nov;153(1):368-74. doi: 10.1016/0003-9861(72)90457-2.
8
Two distinct isocitrate lyases from a pseudomonas species.
J Bacteriol. 1975 May;122(2):557-64. doi: 10.1128/jb.122.2.557-564.1975.
9
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.
10
The biochemistry of methylotrophic micro-organisms.甲基营养型微生物的生物化学
Sci Prog. 1975 Summer;62(246):167-206.

衣康酸对甲基营养型细菌生长的抑制作用。

Inhibition by itaconate of growth of methylotrophic bacteria.

作者信息

Bellion E, Kelley R L

出版信息

J Bacteriol. 1979 May;138(2):519-22. doi: 10.1128/jb.138.2.519-522.1979.

DOI:10.1128/jb.138.2.519-522.1979
PMID:374391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218207/
Abstract

The effects of the isocitrate lyase-directed growth inhibitor itaconate on the growth of certain methylotrophic organisms was investigated. It was found that growth of those organisms possessing the Icl(+)-serine pathway of one-carbon metabolism was inhibited during growth on methylamine and on acetate, but not on glucose. Organisms possessing the Icl(-)-serine pathway pathway were unaffected. Organism PAR, an Icl(-)-serine pathway type, was not specifically inhibited during growth on acetate. This finding further substantiates previous reports of the lack of isocitrate lyase in this organism, indicating a totally new pathway for acetate assimilation.

摘要

研究了异柠檬酸裂解酶导向生长抑制剂衣康酸对某些甲基营养型生物生长的影响。结果发现，那些具有一碳代谢Icl(+) - 丝氨酸途径的生物在甲胺和乙酸盐上生长时受到抑制，但在葡萄糖上生长时不受抑制。具有Icl(-) - 丝氨酸途径的生物不受影响。Icl(-) - 丝氨酸途径类型的生物PAR在乙酸盐上生长时未受到特异性抑制。这一发现进一步证实了此前关于该生物缺乏异柠檬酸裂解酶的报道，表明存在一条全新的乙酸盐同化途径。