衣康酸对甲基营养型细菌生长的抑制作用。
Inhibition by itaconate of growth of methylotrophic bacteria.
作者信息
Bellion E, Kelley R L
出版信息
J Bacteriol. 1979 May;138(2):519-22. doi: 10.1128/jb.138.2.519-522.1979.
Abstract
The effects of the isocitrate lyase-directed growth inhibitor itaconate on the growth of certain methylotrophic organisms was investigated. It was found that growth of those organisms possessing the Icl(+)-serine pathway of one-carbon metabolism was inhibited during growth on methylamine and on acetate, but not on glucose. Organisms possessing the Icl(-)-serine pathway pathway were unaffected. Organism PAR, an Icl(-)-serine pathway type, was not specifically inhibited during growth on acetate. This finding further substantiates previous reports of the lack of isocitrate lyase in this organism, indicating a totally new pathway for acetate assimilation.
摘要
研究了异柠檬酸裂解酶导向生长抑制剂衣康酸对某些甲基营养型生物生长的影响。结果发现，那些具有一碳代谢Icl(+) - 丝氨酸途径的生物在甲胺和乙酸盐上生长时受到抑制，但在葡萄糖上生长时不受抑制。具有Icl(-) - 丝氨酸途径的生物不受影响。Icl(-) - 丝氨酸途径类型的生物PAR在乙酸盐上生长时未受到特异性抑制。这一发现进一步证实了此前关于该生物缺乏异柠檬酸裂解酶的报道，表明存在一条全新的乙酸盐同化途径。
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