He Mei, Wang Wenjing, He Qiang, Dai Heling, Han Jinming, Cui Wenyao
Department of Anesthesiology and Operating Room, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan, China.
Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, China.
Neurol Ther. 2023 Oct;12(5):1695-1707. doi: 10.1007/s40120-023-00525-1. Epub 2023 Jul 13.
The causal association between the gut microbiome and the risk of intracranial aneurysm (IA), subarachnoid hemorrhage (SAH), and unruptured aneurysm (uIA) is unclear.
The single nucleotide polymorphisms concerning gut microbiome were retrieved from the gene-wide association study (GWAS) of the MiBioGen consortium. The summary-level datasets of IA and SAH were obtained from the GWAS meta-analysis of the International Stroke Genetics Consortium (ISGC). Inverse variance weighting (IVW) was utilized as the primary method, complemented with sensitivity analyses for pleiotropy and increasing robustness.
Five, seven, and six bacterial traits were found to have a causal effect on IA, SAH, and uIA, respectively (IVW, all P < 0.05). Family.Porphyromonadaceae and genus.Bilophila were common protective bacterial features for both SAH and uIA. The heterogeneity and pleiotropy analyses confirmed the robustness of IVW results.
Our study demonstrates that gut microbiomes may exert therapeutic effects on IA, uIA, and SAH, providing clinical implications for the development of novel biomarkers and therapeutic targets.
肠道微生物群与颅内动脉瘤（IA）、蛛网膜下腔出血（SAH）和未破裂动脉瘤（uIA）风险之间的因果关系尚不清楚。
从MiBioGen联盟的全基因关联研究（GWAS）中检索与肠道微生物群相关的单核苷酸多态性。IA和SAH的汇总水平数据集来自国际卒中遗传学联盟（ISGC）的GWAS荟萃分析。采用逆方差加权（IVW）作为主要方法，并辅以多效性敏感性分析以增强稳健性。
分别发现5种、7种和6种细菌特征对IA、SAH和uIA有因果效应（IVW，所有P<0.05）。卟啉单胞菌科家族和嗜胆菌属是SAH和uIA共同的保护性细菌特征。异质性和多效性分析证实了IVW结果的稳健性。
我们的研究表明，肠道微生物群可能对IA、uIA和SAH发挥治疗作用，为新型生物标志物和治疗靶点的开发提供临床启示。
