Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.
High Blood Press Cardiovasc Prev. 2024 Nov;31(6):577-612. doi: 10.1007/s40292-024-00681-x. Epub 2024 Nov 16.
Several studies investigated the implication of the gut microbiota (GM) in the formation and progression of aneurysms, suggesting a key role for GM metabolites in aneurysmal pathogenesis and prognosis.
This systematic review aims to collect key findings concerning the impact of gut bacterial compositions, GM-related metabolites, probiotics administration, and inflammatory markers in aneurysmal development and rupture.
A PubMed, Medline, Embase, and Web of Science database search was conducted in accordance with PRISMA guidelines for systematic reviews, targeting all studies assessing the GM's role in aneurysms till 2023.
Data from 19 out of 292 non-duplicated studies were included. Based on the published literature, aneurysmal incidents in several locations were accompanied by an alteration in specific intestinal bacteria that may affect the prognosis of the aneurysm. The gut dysbiosis was also accompanied by modifications in the metabolic pathways. Hence, the administration of specific probiotics showed a significant implication in reversing the GM-related changes that were affecting the aneurysm, leading to a decrease in its severity, a better prognosis, and even serving as a prophylactic approach.
The outcomes of this review highlight the role of GM in the pathogenesis of aneurysms, assessing some involved mechanistic pathways such as gut dysbiosis, inflammation, and the alteration of gut-derived metabolites levels, which orient new research on developing therapeutic strategies.
多项研究探讨了肠道微生物群（GM）在动脉瘤形成和进展中的作用，表明 GM 代谢物在动脉瘤发病机制和预后中起着关键作用。
本系统综述旨在收集有关肠道细菌组成、GM 相关代谢物、益生菌治疗和炎症标志物在动脉瘤发展和破裂中的影响的关键发现。
根据 PRISMA 系统评价指南，对 PubMed、Medline、Embase 和 Web of Science 数据库进行了检索，以检索截至 2023 年所有评估 GM 在动脉瘤中作用的研究。
从 292 篇非重复研究中选出 19 篇数据。根据已发表的文献，在几个部位发生的动脉瘤事件伴随着特定肠道细菌的改变，这可能影响动脉瘤的预后。肠道菌群失调也伴随着代谢途径的改变。因此，特定益生菌的给药在逆转影响动脉瘤的 GM 相关变化方面具有显著意义，导致其严重程度降低、预后更好，甚至可以作为一种预防方法。
本综述的结果强调了 GM 在动脉瘤发病机制中的作用，评估了一些涉及的机制途径，如肠道菌群失调、炎症和肠道衍生代谢物水平的改变，为开发治疗策略提供了新的研究方向。
