Department of Biochemistry and Molecular Biology School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, China.
Key Laboratory of Endemic and Ethenic Diseases Medical Molecular Biology of Guizhou Province Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Chembiochem. 2023 Aug 15;24(16):e202300017. doi: 10.1002/cbic.202300017. Epub 2023 Jul 13.
Ministry of Education and Key Laboratory of Neurons and glial cells of the central nervous system (CNS) are modified by glycosylation and rely on glycosylation to achieve normal neural function. Neurodegenerative disease is a common disease of the elderly, affecting their healthy life span and quality of life, and no effective treatment is currently available. Recent research implies that various glycosylation traits are altered during neurodegenerative diseases, suggesting a potential implication of glycosylation in disease pathology. Herein, we summarized the current knowledge about glycosylation associated with Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Amyotrophic lateral sclerosis (ALS) pathogenesis, focusing on their promising functional avenues. Moreover, we collected research aimed at highlighting the need for such studies to provide a wealth of disease-related glycosylation information that will help us better understand the pathophysiological mechanisms and hopefully specific glycosylation information to provide further diagnostic and therapeutic directions for neurodegenerative diseases.
教育部和中枢神经系统（CNS）神经元和神经胶质细胞重点实验室通过糖基化修饰，依赖糖基化来实现正常的神经功能。神经退行性疾病是老年人的常见病，影响他们的健康寿命和生活质量，目前尚无有效的治疗方法。最近的研究表明，在神经退行性疾病过程中，各种糖基化特征发生改变，提示糖基化可能与疾病的病理有关。在此，我们总结了与阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）和肌萎缩侧索硬化症（ALS）发病机制相关的糖基化的最新知识，重点介绍了它们有前途的功能途径。此外，我们还收集了旨在强调需要开展此类研究的相关研究，以提供大量与疾病相关的糖基化信息，帮助我们更好地理解病理生理机制，并希望提供特定的糖基化信息，为神经退行性疾病提供进一步的诊断和治疗方向。
