Laboratory of Physiopathology, Molecular Genetics & Biotechnology, Faculty of Sciences Ain Chock, Health and Biotechnology Research Centre, Hassan II University of Casablanca, Maarif B.P 5366, Casablanca, Morocco.
Laboratory of Medical Analysis, Andrology, LABOMAC, Casablanca, Morocco.
ScientificWorldJournal. 2023 Jun 24;2023:8093795. doi: 10.1155/2023/8093795. eCollection 2023.
Male infertility is a complex multifactorial disease and a real health problem; 50% of infertile men have identifiable causes detectable by fundamental sperm analysis. Numerous research studies have shown the possibility of treating abnormal semen samples with some drugs before artificial insemination, yet evidence of the drug's effectiveness remains minimal. In our previous work, we tested the effectiveness of some essential oils, such as eucalyptus ( Labill.), oregano ( L.), and sage ( L.) on sperm parameters. The essential oil of oregano showed the best ameliorative effect. In present, we examined the effect of the essential oil of on the physiological parameters and the specific activity of certain antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), lipid peroxidation rate (MDA), and GAPDH and antioxidant and metabolic biomarkers, characterizing the quality of human sperm. The results showed that supplementation of oregano significantly improves the mobility and antioxidant activities, without harmful effects on the integrity of the sperm's DNA, and that the selected concentration of oregano EO is nontoxic and may be considered a therapeutic alternative to heal sperm motility problems in asthenozoospermic patients.
男性不育是一种复杂的多因素疾病，也是一个真正的健康问题；50%的不育男性有可通过基本精子分析检测到的可识别原因。许多研究表明，在人工授精前，一些药物有可能治疗异常的精液样本，但药物有效性的证据仍然很少。在我们之前的工作中，我们测试了一些精油，如桉树（Labill.）、牛至（L.）和鼠尾草（L.）对精子参数的有效性。牛至精油显示出最好的改善效果。目前，我们研究了丁香酚对生理参数和某些抗氧化酶（如过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、脂质过氧化率（MDA）和 GAPDH）以及抗氧化和代谢生物标志物的特异性活性的影响，这些标志物可表征人精子的质量。结果表明，丁香酚的补充显著提高了精子的运动能力和抗氧化活性，而对精子 DNA 的完整性没有有害影响，并且所选浓度的牛至精油 EO 是无毒的，可被认为是治疗弱精症患者精子运动问题的一种替代方法。
