The synchronous harvesting and conversion of multiple renewable energy sources for chemical fuel production and environmental remediation in a single system is a holy grail in sustainable energy technologies. However, it is challenging to develop advanced energy harvesters that satisfy different working mechanisms. Here, we theoretically and experimentally disclose the use of MXene materials as versatile catalysts for multi-energy utilization. TiCT MXene shows remarkable catalytic performance for organic pollutant decomposition and H production. It outperforms most reported catalysts under the stimulation of light, thermal, and mechanical energy. Moreover, the synergistic effects of piezo-thermal and piezo-photothermal catalysis further improve the performance when using TiCT. A mechanistic study reveals that hydroxyl and superoxide radicals are produced on the TiCT under diverse energy stimulation. Furthermore, similar multi-functionality is realized in TiCT, VCT, and NbCT MXene materials. This work is anticipated to open a new avenue for multisource renewable energy harvesting using MXene materials.