Mayor G H, Keiser J A, Sanchez T V, Sprague S M, Hook J B
J Dial. 1978;2(5-6):471-81. doi: 10.3109/08860227809080100.
Elevated concentration of aluminum has been reported in serum, whole blood and tissue samples of patients with renal insufficiency. Evidence incriminating aluminum as a neurotoxin among the dialysis population is strong. The source of this aluminum has not been clearly defined, although both gastrointestinal and parenteral routes may be involved. Data from this laboratory suggest that an effect of parathyroid hormone on tissue aluminum burdens may, in part, explain why only certain patients exposed to high dialysate aluminum develop the dialysis encephalopathy syndrome and the occasional occurrence of this syndrome in the absence of dialysis or increased dialysate aluminum.
据报道，肾功能不全患者的血清、全血和组织样本中铝浓度升高。在透析人群中，有充分证据表明铝是一种神经毒素。尽管胃肠道和肠外途径都可能涉及，但这种铝的来源尚未明确界定。本实验室的数据表明，甲状旁腺激素对组织铝负荷的影响可能在一定程度上解释了为什么只有某些暴露于高透析液铝的患者会出现透析脑病综合征，以及为什么在没有透析或透析液铝增加的情况下偶尔会出现这种综合征。
