Mayor G H, Keiser J A, Makdani D, Ku P K
Science. 1977 Sep 16;197(4309):1187-9. doi: 10.1126/science.897661.
In rats, gastrointestinal aluminum absorption and tissue distribution were altered by parathyroid hormone; the resultant tissue concentrations were similar to those observed in dialysis patients with a fatal encephalopathy. In dialysis patients, serum aluminum and endogenous parathyroid hormone concentrations are significantly correlated. These data suggest that aluminum toxicity in dialysis patients results from oral aluminum ingestion in the presence of hyperparathyroidism.
在大鼠中，甲状旁腺激素改变了胃肠道对铝的吸收及组织分布；由此产生的组织铝浓度与在患有致命性脑病的透析患者中观察到的浓度相似。在透析患者中，血清铝浓度与内源性甲状旁腺激素浓度显著相关。这些数据表明，透析患者的铝中毒是在甲状旁腺功能亢进情况下经口摄入铝所致。
