甲状旁腺激素介导的大鼠体内铝沉积与排出

Parathyroid hormone-mediated aluminum deposition and egress in the rat.

作者信息

Mayor G H, Sprague S M, Hourani M R, Sanchez T V

出版信息

Kidney Int. 1980 Jan;17(1):40-4. doi: 10.1038/ki.1980.5.

DOI:10.1038/ki.1980.5

Abstract

Exogenous PTH significantly enhances tissue aluminum concentration in normal rats fed an aluminum-supplemented diet. In this study, we examined the effect of PTH withdrawal on brain and whole carcass aluminum concentrations. Four groups of rats were fed an aluminum diet while receiving injections of PTH for 5 days. On day 5, one group of rats was sacrificed, and the treatment regimen of the remaining groups altered. PTH, the aluminum diet, or PTH and the aluminum diet were withdrawn respectively for an additional 5 days. An additional group of rats was fed the aluminum diet for 10 days. PTH dramatically increased the concentration of aluminum in both brain and carcass above that found in tissues of rats given aluminum alone. Brain and whole carcass aluminum concentrations remained elevated in rats continued on PTH even in the absence of continued supplemental dietary aluminum. In contrast, following PTH withdrawal, brain and whole carcass aluminum concentrations were significantly lower and independent of dietary aluminum. Thus, PTH may be an important mediator of specific tissue aluminum burdens.

摘要

外源性甲状旁腺激素（PTH）可显著提高喂食高铝饮食的正常大鼠的组织铝浓度。在本研究中，我们检测了停用PTH对脑和整个胴体铝浓度的影响。四组大鼠喂食高铝饮食，同时接受PTH注射，持续5天。在第5天，处死一组大鼠，并改变其余组的治疗方案。分别停用PTH、高铝饮食或PTH与高铝饮食，再持续5天。另一组大鼠喂食高铝饮食10天。PTH使脑和胴体中的铝浓度显著高于仅喂食铝的大鼠组织中的浓度。即使在没有持续补充饮食铝的情况下，继续接受PTH的大鼠的脑和整个胴体铝浓度仍保持升高。相比之下，停用PTH后，脑和整个胴体铝浓度显著降低，且与饮食铝无关。因此，PTH可能是特定组织铝负荷的重要介质。