Gibellini Lara, Borella Rebecca, Santacroce Elena, Serattini Eugenia, Boraldi Federica, Quaglino Daniela, Aramini Beatrice, De Biasi Sara, Cossarizza Andrea
Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Cancers (Basel). 2023 Jun 24;15(13):3327. doi: 10.3390/cancers15133327.
Neutrophils are the most abundant myeloid cells in the blood and are a considerable immunological component of the tumor microenvironment. However, their functional importance has often been ignored, as they have always been considered a mono-dimensional population of terminally differentiated, short-living cells. During the last decade, the use of cutting-edge, single-cell technologies has revolutionized the classical view of these cells, unmasking their phenotypic and functional heterogeneity. In this review, we summarize the emerging concepts in the field of neutrophils in cancer, by reviewing the recent literature on the heterogeneity of both circulating neutrophils and tumor-associated neutrophils, as well as their possible significance in tumor prognosis and resistance to immune checkpoint inhibitors.
中性粒细胞是血液中最丰富的髓样细胞，是肿瘤微环境中相当重要的免疫组成部分。然而，它们的功能重要性常常被忽视，因为它们一直被认为是终末分化、寿命短暂的单一类型细胞群体。在过去十年中，前沿的单细胞技术的应用彻底改变了对这些细胞的传统看法，揭示了它们的表型和功能异质性。在这篇综述中，我们通过回顾关于循环中性粒细胞和肿瘤相关中性粒细胞异质性的最新文献，以及它们在肿瘤预后和对免疫检查点抑制剂耐药性方面的可能意义，总结了癌症领域中性粒细胞的新出现的概念。
