Cicogna Stefania, Dellino Miriam, Miano Salvatora Tindara, Magazzino Francescapaola, Domenici Lavinia, Pignata Sandro, Mangili Giorgia, Cormio Gennaro
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34145 Trieste, Italy.
Department of Interdisciplinary Medicine (DIM), University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.
Cancers (Basel). 2023 Jun 29;15(13):3403. doi: 10.3390/cancers15133403.
Deep (aggressive) angiomyxoma of the lower genital tract is a rare malignancy affecting women of reproductive age. Being a hormone-sensitive tumor, its growth is particularly benefitted during pregnancy. Surgical excision with complete resection is indicated, even if a wait-and-see approach can be considered until delivery, to avoid destructive surgeries. The mode of delivery is to be evaluated based on the location and size of the neoplasm; vaginal delivery is not contraindicated, as long as the tumor does not obstruct the birth canal. Positive surgical margins are the most important prognostic factor for recurrence. Adjuvant therapy with gonadotropin-releasing hormone analogues may be proposed after pregnancy, in the case of non-radical surgery. Despite the high local relapse rate, the outcomes for mother and child are favorable. Since recurrences can occur after many years, the patient should be included in long-term follow-up.
下生殖道深部（侵袭性）血管黏液瘤是一种罕见的恶性肿瘤，影响育龄女性。作为一种激素敏感性肿瘤，其生长在孕期尤其受益。即使在分娩前可考虑采取观察等待的方法，但仍建议进行完整切除的手术切除，以避免破坏性手术。分娩方式需根据肿瘤的位置和大小进行评估；只要肿瘤不妨碍产道，阴道分娩并非禁忌。手术切缘阳性是复发的最重要预后因素。对于非根治性手术，妊娠后可考虑使用促性腺激素释放激素类似物进行辅助治疗。尽管局部复发率高，但母婴结局良好。由于复发可能在多年后发生，患者应纳入长期随访。
