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斜坡脊索瘤多模式治疗后的长期疗效：鼻内镜经斜坡入路联合早期辅助放疗的疗效

Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy.

作者信息

Yoo Hyun Dong, Chung Jong Chul, Park Ki Seok, Chung Seung Young, Park Moon Sun, Ryu Seungjun, Kim Seong Min

机构信息

Department of Neurosurgery, Eulji University Hospital, Eulji University College of Medicine, Daejeon 35233, Republic of Korea.

Center for Neuromodulation, Department of Neurosurgery, NYU Langone Medical Center, New York, NY 11021, USA.

出版信息

J Clin Med. 2023 Jul 3;12(13):4460. doi: 10.3390/jcm12134460.

DOI:10.3390/jcm12134460
PMID:37445495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10342406/
Abstract

This study investigates the long-term outcomes of clival chordoma patients treated with the endonasal transclival approach (ETCA) and early adjuvant radiation therapy. A retrospective review of 17 patients (2002-2013) showed a 10-year progression-free survival (PFS) rate of 67.4%, with the ETCA group showing fewer progressions and cranial neuropathies than those treated with combined approaches. The ETCA, a minimally invasive technique, provided a similar extent of resection compared to conventional skull-base approaches and enabled safe delivery of high-dose adjuvant radiotherapy. The findings suggest that ETCA is an effective treatment for centrally located clival chordomas.

摘要

本研究调查了采用经鼻经斜坡入路（ETCA）及早期辅助放疗的斜坡脊索瘤患者的长期预后。对17例患者（2002年至2013年）的回顾性研究显示，10年无进展生存率（PFS）为67.4%，与联合治疗方法相比，ETCA组的进展和颅神经病变较少。ETCA作为一种微创技术，与传统颅底入路相比，切除范围相似，且能够安全地进行高剂量辅助放疗。研究结果表明，ETCA是治疗位于中央的斜坡脊索瘤的有效方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/ab5fc2165c9f/jcm-12-04460-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/6d518ca506b7/jcm-12-04460-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/f092dc4cfeb5/jcm-12-04460-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/f54fa7f27a1c/jcm-12-04460-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/f45e742bf053/jcm-12-04460-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/ab5fc2165c9f/jcm-12-04460-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/6d518ca506b7/jcm-12-04460-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/f092dc4cfeb5/jcm-12-04460-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/f54fa7f27a1c/jcm-12-04460-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/f45e742bf053/jcm-12-04460-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7008/10342406/ab5fc2165c9f/jcm-12-04460-g005.jpg

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本文引用的文献

1
Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival.骶骨脊索瘤的外科治疗：局部复发和总生存的预后变量
Eur Spine J. 2015 May;24(5):1092-101. doi: 10.1007/s00586-014-3728-6. Epub 2014 Dec 23.
2
Radiosurgery with photons or protons for benign and malignant tumours of the skull base: a review.颅底良、恶性肿瘤的光子或质子放射外科治疗：综述。
Radiat Oncol. 2012 Dec 14;7:210. doi: 10.1186/1748-717X-7-210.
3
Photon-based fractionated stereotactic radiotherapy for postoperative treatment of skull base chordomas.
J Med Radiat Sci. 2024 Apr;71 Suppl 2(Suppl 2):47-58. doi: 10.1002/jmrs.774. Epub 2024 Mar 19.
4
Skull Base Tumors: Therapeutic Challenges and Multi-Disciplinary Care.颅底肿瘤：治疗挑战与多学科护理
Cancers (Basel). 2024 Jan 31;16(3):620. doi: 10.3390/cancers16030620.
基于光子的分次立体定向放射治疗用于颅底脊索瘤术后治疗。
Am J Clin Oncol. 2013 Aug;36(4):404-10. doi: 10.1097/COC.0b013e318248dc6f.
4
Endoscopic endonasal approach for resection of cranial base chordomas: outcomes and learning curve.经鼻内镜颅底脊索瘤切除术：结果和学习曲线。
Neurosurgery. 2012 Sep;71(3):614-24; discussion 624-5. doi: 10.1227/NEU.0b013e31825ea3e0.
5
Chordoma: current concepts, management, and future directions.脊索瘤：当前概念、管理和未来方向。
Lancet Oncol. 2012 Feb;13(2):e69-76. doi: 10.1016/S1470-2045(11)70337-0.
6
Current therapeutic options and novel molecular markers in skull base chordomas.颅底脊索瘤的当前治疗选择和新型分子标志物。
Neurosurg Rev. 2012 Jan;35(1):1-13; discussion 13-4. doi: 10.1007/s10143-011-0354-1. Epub 2011 Oct 18.
7
Skull base chordomas.颅底脊索瘤
Otolaryngol Clin North Am. 2011 Oct;44(5):1155-71. doi: 10.1016/j.otc.2011.06.002. Epub 2011 Jul 21.
8
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J Neurosurg. 2011 Dec;115(6):1094-105. doi: 10.3171/2011.7.JNS11355. Epub 2011 Aug 5.
9
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10
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World Neurosurg. 2010 Mar;73(3):194-7; discussion e31. doi: 10.1016/j.surneu.2009.01.003. Epub 2009 Mar 29.