Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Int J Mol Sci. 2023 Jun 21;24(13):10422. doi: 10.3390/ijms241310422.
Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin-oral-gut axis. In addition, many studies have evaluated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field.
人类血液在历史上一直被认为是无菌的环境。最近，在健康的血液中发现了一个以厚壁菌门、放线菌门、变形菌门和拟杆菌门为主的微生物群。这些微生物的定位仅限于一些血细胞群体，特别是外周血单核细胞和红细胞。有人假设血液微生物组来源于皮肤-口腔-肠道轴。此外，许多研究评估了血液微生物组失调作为心血管疾病、肝硬化、严重肝纤维化、重症急性胰腺炎、2 型糖尿病和慢性肾脏病的预后标志物的潜力。本综述旨在总结该领域目前的发现和最新证据。
