Mohammadi Masoumeh, Aboonajmi Jasem, Panahi Farhad, Sasanipour Maryam, Sharghi Hashem
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, Fars, 71454, Iran.
Sci Rep. 2024 Oct 29;14(1):25973. doi: 10.1038/s41598-024-76839-3.
In this study, an efficient method for the synthesis of benzoxazoles by coupling catechols, aldehydes and ammonium acetate using ZrCl as catalyst in ethanol is reported. A wide range of benzoxazoles (59 examples) are smoothly produced in high yields (up to 97%). Other advantages of the method include large-scale synthesis and the use of oxygen as an oxidant. The mild reaction conditions allowed late-stage functionalization, facilitating access to several derivatives with biologically relevant structures such as β-lactam and quinoline heterocycles.
本研究报道了一种在乙醇中以ZrCl为催化剂，通过邻苯二酚、醛和醋酸铵偶联合成苯并恶唑的有效方法。多种苯并恶唑（59个实例）能以高产率（高达97%）顺利生成。该方法的其他优点包括大规模合成以及使用氧气作为氧化剂。温和的反应条件允许进行后期官能化，便于获得几种具有生物学相关结构的衍生物，如β-内酰胺和喹啉杂环。
