Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
College of Nursing, King Saud University, Riyadh 11451, Saudi Arabia.
Molecules. 2023 Jun 29;28(13):5084. doi: 10.3390/molecules28135084.
Potassium bromate (PB) is a general food additive, a significant by-product during water disinfection, and a carcinogen (Class II B). The compound emits toxicity depending on the extent of its exposure and dose through consumable items. The current study targeted disclosing the ameliorative efficacy of zinc oxide nanoparticles (ZnO NPs) prepared by green technology in PB-exposed Swiss albino rats. The rats were separated into six treatment groups: control without any treatment (Group I), PB alone (Group II), ZnO alone (Group III), ZnO NP alone (Group IV), PB + ZnO (Group V), and PB + ZnO NPs (Group VI). The blood and kidney samples were retrieved from the animals after following the treatment plan and kept at -20 °C until further analysis. Contrary to the control (Group I), PB-treated rats (Group II) exhibited a prominent trend in alteration in the established kidney function markers and disturbed redox status. Further, the analysis of the tissue and nuclear DNA also reinforced the biochemical results of the same treatment group. Hitherto, Groups III and IV also showed moderate toxic insults. However, Group VI showed a significant improvement from the PB-induced toxic insults compared to Group II. Hence, the present study revealed the significant therapeutic potential of the NPs against PB-induced nephrotoxicity in vivo, pleading for their usage in medicines having nephrotoxicity as a side effect or in enhancing the safety of the industrial use of PB.
溴酸钾 (PB) 是一种通用食品添加剂，也是水消毒过程中的一种重要副产物，同时还是一种致癌物质（二类 B 级）。该化合物的毒性取决于其暴露程度和通过可食用物品摄入的剂量。本研究旨在揭示通过绿色技术制备的氧化锌纳米粒子 (ZnO NPs) 对暴露于 PB 的瑞士白化大鼠的改善效果。将大鼠分为六组进行治疗：未进行任何处理的对照组（I 组）、单独 PB 处理组（II 组）、单独 ZnO 处理组（III 组）、单独 ZnO NPs 处理组（IV 组）、PB+ZnO 处理组（V 组）和 PB+ZnO NPs 处理组（VI 组）。按照治疗方案处理完动物后，从它们身上取出血液和肾脏样本，储存在-20°C 直至进一步分析。与对照组（I 组）相比，PB 处理组（II 组）的大鼠表现出明显的肾脏功能标志物改变和氧化还原状态紊乱的趋势。此外，组织和核 DNA 的分析也强化了同一处理组的生化结果。迄今为止，III 组和 IV 组也表现出中度的毒性损伤。然而，与 II 组相比，VI 组显示出对 PB 诱导的毒性损伤有显著的改善。因此，本研究揭示了 NPs 对体内 PB 诱导的肾毒性的显著治疗潜力，呼吁将其用于具有肾毒性副作用的药物中，或用于增强 PB 工业用途的安全性。
