Wang Fang, Zhong Huanhuan, Fang Shiqi, Zheng Yunfeng, Li Cunyu, Peng Guoping, Shen Xinchun
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
College of food science and Engineering, Nanjing University of Finance and Economics, Nanjing, P. R. China.
Planta Med. 2018 Jan;84(2):123-128. doi: 10.1055/s-0043-117742. Epub 2017 Aug 9.
has traditionally been used as folk medicine in Asian countries for its therapeutic effects on tracheitis and tonsillitis. Investigation of the anti-inflammatory active constituents from led to the isolation of two novel sesquiterpene lactones, named eupalinolide L (1: ) and eupalinolide M (2: ), and seven known sesquiterpene lactones (3: -9: ). The structures and configurations of the new compounds were determined on the basis of spectroscopic analysis, especially 2D NMR techniques. experiments showed that the sesquiterpenes fraction significantly reduced mouse ear edema induced by xylene (18.6%, p < 0.05). In assays, compounds 1: -9: showed excellent anti-inflammatory activities, as they lowered TNF- and IL-6 levels in lipopolysaccharide-stimulated murine macrophage RAW 264.7 cells (p < 0.001). The above results suggest that the sesquiterpene lactones from can be developed as novel potential natural anti-inflammatory agents.
在亚洲国家，它传统上一直被用作治疗气管炎和扁桃体炎的民间药物。对其抗炎活性成分的研究导致分离出两种新型倍半萜内酯，分别命名为泽兰内酯L（1： ）和泽兰内酯M（2： ），以及七种已知的倍半萜内酯（3： - 9： ）。新化合物的结构和构型是基于光谱分析，特别是二维核磁共振技术确定的。实验表明，倍半萜馏分显著降低了二甲苯诱导的小鼠耳肿胀（18.6%，p < 0.05）。在检测中，化合物1： - 9： 表现出优异的抗炎活性，因为它们降低了脂多糖刺激的小鼠巨噬细胞RAW 264.7细胞中的肿瘤坏死因子和白细胞介素-6水平（p < 0.001）。上述结果表明，来自 的倍半萜内酯可被开发为新型潜在的天然抗炎剂。
