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博伊斯衍生的银纳米颗粒及其作为纳米治疗剂用于控制微生物和氧化应激引发疾病的应用。

Boiss Derived Silver Nanoparticles and Their Applications as a Nanotherapeutic Agent to Control Microbial and Oxidative Stress-Originated Diseases.

作者信息

Ullah Rehman, Jan Saiqa Afriq, Khan Muhammad Nauman, Nazish Moona, Kamal Asif, Kaplan Alevcan, Yehia Hany M, Alarjani Khaloud Mohammed, Alkasir Rashad, Zaman Wajid

机构信息

Pharmacognosy Laboratory, Department of Botany, Faculty of Life and Environmental Sciences, University of Peshawar, Peshawar 25120, Pakistan.

Department of Botany, Islamia College Peshawar, Peshawar 25120, Pakistan.

出版信息

Pharmaceuticals (Basel). 2023 Oct 4;16(10):1413. doi: 10.3390/ph16101413.

DOI:10.3390/ph16101413
PMID:37895884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10609787/
Abstract

Nanotechnology is one of the most advance and multidisciplinary fields. Recent advances in nanoscience and nanotechnology radically changed the way we diagnose, treat, and prevent various diseases in all aspects of human life. The use of plants and their extracts is one of the most valuable methods towards rapid and single-step protocol preparation for various nanoparticles, keeping intact "the green principles" over the conventional ones and proving their dominance for medicinal importance. A facile and eco-friendly technique for synthesizing silver nanoparticles has been developed by using the latex of as a bio-reductant for reducing Ag+ ions in an aqueous solution. Various characterization techniques were employed to validate the morphology, structure, and size of nanoparticles via UV-Vis spectroscopy, XRD, SEM, and EDS. FTIR spectroscopy validates different functional groups associated with biomolecules stabilizing/capping the silver nanoparticles, while SEM and XRD revealed spherical nanocrystals with FCC geometry. The results revealed that latex extract-mediated silver nanoparticles (LER-AgNPs) exhibited promising antibacterial activity against both gram-positive and -negative bacterial strains (, , , , and ). Both latex of and LER-AgNPs were found to be potent in scavenging DPPH free radicals with respective EC50s and EC70s as 0.267% and 0.518% and 0.287% and 0.686%. ROSs produced in the body damage tissue and cause inflammation in oxidative stress-originated diseases. HO and OH* scavenging activity increased with increasing concentrations (20-100 μg/mL) of LER-AgNPs. Significant reestablishment of ALT, AST, ALP, and bilirubin serum levels was observed in mice intoxicated with acetaminophen (PCM), revealing promising hepatoprotective efficacy of LER-AgNPs in a dose-dependent manner.

摘要

纳米技术是最先进的多学科领域之一。纳米科学和纳米技术的最新进展从根本上改变了我们在人类生活各个方面诊断、治疗和预防各种疾病的方式。利用植物及其提取物是制备各种纳米颗粒快速单步方案最有价值的方法之一，与传统方法相比，它保持了“绿色原则”，并证明了其在药用方面的优势。通过使用[植物名称]的乳胶作为生物还原剂在水溶液中还原Ag+离子，开发了一种简便且环保的合成银纳米颗粒的技术。采用各种表征技术通过紫外可见光谱、X射线衍射、扫描电子显微镜和能谱来验证纳米颗粒的形态、结构和尺寸。傅里叶变换红外光谱验证了与稳定/包覆银纳米颗粒的生物分子相关的不同官能团，而扫描电子显微镜和X射线衍射显示具有面心立方几何结构的球形纳米晶体。结果表明，乳胶提取物介导的银纳米颗粒（LER-AgNPs）对革兰氏阳性和阴性细菌菌株（[具体细菌名称列举]）均表现出有前景的抗菌活性。发现[植物名称]的乳胶和LER-AgNPs在清除DPPH自由基方面都很有效，其各自的半数有效浓度（EC50）和百分之七十有效浓度（EC70）分别为0.267%和0.518%以及0.287%和0.686%。体内产生的活性氧会损伤组织并在氧化应激引发的疾病中引起炎症。随着LER-AgNPs浓度（20 - 100μg/mL）的增加，羟基自由基（HO·）和氢氧根离子自由基（OH*）清除活性增强。在用对乙酰氨基酚（PCM）中毒的小鼠中观察到谷丙转氨酶（ALT）、谷草转氨酶（AST）、碱性磷酸酶（ALP）和胆红素血清水平显著恢复，这表明LER-AgNPs具有剂量依赖性的有前景的肝脏保护功效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/2c4122f2e8c3/pharmaceuticals-16-01413-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/69aa89c919c1/pharmaceuticals-16-01413-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/f5a5e14764c3/pharmaceuticals-16-01413-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/a356bf3298e6/pharmaceuticals-16-01413-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/b8f128871691/pharmaceuticals-16-01413-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/2c4122f2e8c3/pharmaceuticals-16-01413-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/29bed46a3286/pharmaceuticals-16-01413-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/3b60a6952c8f/pharmaceuticals-16-01413-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/5737bcf02515/pharmaceuticals-16-01413-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/3cdef61df8c1/pharmaceuticals-16-01413-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/ac00d9228d4d/pharmaceuticals-16-01413-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/b944cfc6819c/pharmaceuticals-16-01413-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/752ad1865990/pharmaceuticals-16-01413-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/69aa89c919c1/pharmaceuticals-16-01413-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/f5a5e14764c3/pharmaceuticals-16-01413-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/a356bf3298e6/pharmaceuticals-16-01413-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/e68a0fb4fd72/pharmaceuticals-16-01413-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/b8f128871691/pharmaceuticals-16-01413-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/3cd079f40910/pharmaceuticals-16-01413-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be57/10609787/2c4122f2e8c3/pharmaceuticals-16-01413-g013.jpg

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