DNA 相互作用与 -四(2-噻吩基)卟啉与多吡啶 Pd(II)和 Pt(II)配合物的损伤研究。
DNA-Interactive and Damage Study with -Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes.
机构信息
Bioinorganic and Porphyrinoids Materials Laboratory, Department of Chemistry, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil.
Laboratory of Photobiology, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil.
出版信息
Molecules. 2023 Jul 5;28(13):5217. doi: 10.3390/molecules28135217.
We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (, and ). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes ( and ) were able to promote photo-damage in the DNA.
我们报告了三种带有外围噻吩取代基的卟啉（、和）的 DNA 结合特性。通过紫外-可见光谱和稳态荧光发射光谱结合分子对接计算，确定了每种卟啉与 DNA 的结合能力。结果表明，这些化合物的相互作用可能通过 DNA 大分子周围的外部沟槽（小沟）发生次级相互作用。此外，含有外围 Pd(II)或 Pt(II)配合物的卟啉（和）能够促进 DNA 的光损伤。
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