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止血策略及纳米材料在止血方面的最新进展

Hemostasis Strategies and Recent Advances in Nanomaterials for Hemostasis.

机构信息

Suining Municipal Hospital of Traditional Chinese Medicine, Suining 629000, China.

Center For Peak of Excellence on Biological Science and Food Engineering, National University of Singapore (Suzhou) Research Institute, Suzhou 215004, China.

出版信息

Molecules. 2023 Jul 7;28(13):5264. doi: 10.3390/molecules28135264.

Abstract

The development of materials that effectively stop bleeding and prevent wound adhesion is essential in both military and medical fields. However, traditional hemostasis methods, such as cautery, tourniquets, and gauze, have limitations. In recent years, new nanomaterials have gained popularity in medical and health fields due to their unique microstructural advantages. Compared to traditional materials, nanomaterials offer better adhesion, versatility, and improved bioavailability of traditional medicines. Nanomaterials also possess advantages such as a high degree and stability, self-degradation, fewer side effects, and improved wound healing, which make them ideal for the development of new hemostatic materials. Our review provides an overview of the currently used hemostatic strategies and materials, followed by a review of the cutting-edge nanomaterials for hemostasis, including nanoparticles and nanocomposite hydrogels. The paper also briefly describes the challenges faced by the application of nanomaterials for hemostasis and the prospects for their future development.

摘要

在军事和医疗领域,开发能够有效止血和防止伤口粘连的材料至关重要。然而,传统的止血方法,如烧灼、止血带和纱布,存在局限性。近年来,由于具有独特的微观结构优势,新型纳米材料在医疗保健领域受到关注。与传统材料相比,纳米材料具有更好的粘附性、多功能性和传统药物的生物利用度提高。纳米材料还具有高程度和稳定性、自降解、较少副作用和改善伤口愈合等优点,使其成为开发新型止血材料的理想选择。我们的综述概述了目前使用的止血策略和材料,接着回顾了用于止血的前沿纳米材料,包括纳米颗粒和纳米复合水凝胶。本文还简要描述了纳米材料在止血应用中面临的挑战以及它们未来发展的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adb5/10343471/ba8f69d49668/molecules-28-05264-g001.jpg

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