Kinesiology Department, Seattle University, Seattle, WA 98122, USA.
Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC 27402, USA.
Nutrients. 2023 Jul 6;15(13):3050. doi: 10.3390/nu15133050.
While there is some research investigating whole foods or diets that are easily understood and accessible to patients with osteoarthritis, specific nutrients or nutraceuticals are more commonly identified. Unfortunately, guidelines and evidence surrounding individual nutrients, extracts, and nutraceuticals are conflicting and are more difficult to interpret and implement for patients with osteoarthritis. The purpose of this umbrella review is to provide a comprehensive understanding of the existing evidence of whole foods and dietary patterns effects on osteoarthritis-related outcomes to inform evidence-based recommendations for healthcare professionals and identify areas where more research is warranted. A literature search identified relevant systematic reviews/meta-analyses using five databases from inception to May 2022. Five systematic reviews/meta-analyses were included in the current umbrella review. Most evidence supported the Mediterranean diet improving osteoarthritis-related outcomes (e.g., pain, stiffness, inflammation, biomarkers of cartilage degeneration). There was little to no evidence supporting the effects of fruits and herbs on osteoarthritis-related outcomes; however, there was some suggestion that specific foods could potentiate symptom improvement through antioxidative mechanisms. The overall lack of homogeneity between the studies limits the conclusions that can be made and highlights the need for quality research that can identify consumer-accessible foods to improve osteoarthritis-related symptoms.
虽然有一些研究调查了全食物或饮食，这些饮食容易被骨关节炎患者理解和接受，但更常见的是确定了特定的营养物质或营养保健品。不幸的是，围绕个别营养物质、提取物和营养保健品的指南和证据相互矛盾，对于骨关节炎患者来说，这些证据更难理解和实施。本综述的目的是全面了解全食物和饮食模式对骨关节炎相关结果的现有证据，为医疗保健专业人员提供循证建议，并确定需要进一步研究的领域。文献检索从开始到 2022 年 5 月，使用五个数据库确定了相关的系统评价/荟萃分析。目前的综述共纳入了五项系统评价/荟萃分析。大多数证据支持地中海饮食改善骨关节炎相关结果（例如疼痛、僵硬、炎症、软骨退化生物标志物）。几乎没有证据支持水果和草药对骨关节炎相关结果的影响；然而，有一些迹象表明，某些食物可以通过抗氧化机制增强症状改善。研究之间缺乏同质性限制了可以得出的结论，并强调需要进行高质量的研究，以确定可改善骨关节炎相关症状的消费者可获得的食物。
