Department of Physical Therapy, Institute of Basic Science, Hoseo University, Asan 31499, Republic of Korea.
Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan 31499, Republic of Korea.
Nutrients. 2023 Jul 7;15(13):3062. doi: 10.3390/nu15133062.
Chronic obstructive pulmonary disease (COPD) is a complex, progressive respiratory disorder with persistent airflow limitation and tissue destruction. We aimed to explore the genetic impact of COPD and its interaction with nutrient intake in 8840 middle-aged and elderly individuals from the Ansan/Ansung cohorts. Participants were diagnosed with COPD if the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) was less than 0.7 using spirometry, and if they were previously diagnosed with COPD by a physician. Genome-wide association studies (GWAS) were performed to screen for genetic variants associated with COPD risk. Among them, we selected the genetic variants that exhibited interactions using the generalized multifactor dimensionality reduction (GMDR) method. The polygenic risk score (PRS) was computed by summing the number of risk alleles in the SNP-SNP interaction models that adhered to specific rules. Subsequently, participants were categorized into low-PRS, medium-PRS, and high-PRS groups. The participants with COPD exhibited significantly lower FEV1/FVC ratios (0.64) than those without COPD (0.82). It was positively associated with inflammation markers (serum C-reactive protein and white blood cell levels). A higher proportion of COPD participants were smokers and engaged in regular exercise. The 5-SNP model consisted of _rs1585258, _rs1997571, _rs719601, _rs10405598, and _rs889294, and showed a significant association with COPD risk ( < 0.001). Participants in the high-PRS group of this model had a 2.2-fold higher risk of COPD than those in the low-PRS group after adjusting for covariates. The PRS interacted with w-3 fatty acid intake and exercise, thus influencing the risk of COPD. There was an increase in COPD incidence among individuals with a higher PRS, particularly those with low consumption of w-3 fatty acid and engaged in high levels of exercise. In conclusion, adults with a high-PRS are susceptible to COPD risk, and w-3 fatty acid intake and exercise may impact the risk of developing COPD, potentially applying to formulate precision medicines to prevent COPD.
慢性阻塞性肺疾病（COPD）是一种复杂的、进行性的呼吸系统疾病，其特征是持续的气流受限和组织破坏。我们旨在探讨 COPD 的遗传影响及其与 8840 名中老年人营养摄入的相互作用，这些人来自安山/安城队列。通过肺活量测定法，如果 1 秒用力呼气量（FEV1）与用力肺活量（FVC）的比值小于 0.7，参与者被诊断为 COPD，如果他们之前被医生诊断为 COPD，则也被诊断为 COPD。进行了全基因组关联研究（GWAS），以筛选与 COPD 风险相关的遗传变异。其中，我们使用广义多因子降维（GMDR）方法选择表现出相互作用的遗传变异。通过将符合特定规则的 SNP-SNP 相互作用模型中的风险等位基因数量相加来计算多基因风险评分（PRS）。随后，将参与者分为低 PRS、中 PRS 和高 PRS 组。患有 COPD 的参与者的 FEV1/FVC 比值明显低于没有 COPD 的参与者（0.64）（0.82）。它与炎症标志物（血清 C 反应蛋白和白细胞水平）呈正相关。更多患有 COPD 的参与者是吸烟者且经常运动。5-SNP 模型由 _rs1585258、_rs1997571、_rs719601、_rs10405598 和 _rs889294 组成，与 COPD 风险显著相关（<0.001）。在调整了协变量后，该模型中高 PRS 组的参与者患 COPD 的风险比低 PRS 组高 2.2 倍。PRS 与 w-3 脂肪酸摄入和运动相互作用，从而影响 COPD 的风险。PRS 较高的个体 COPD 发病率增加，特别是那些 w-3 脂肪酸摄入量低且运动水平高的个体。总之，高 PRS 的成年人易患 COPD 风险，w-3 脂肪酸摄入和运动可能会影响患 COPD 的风险，这可能适用于制定预防 COPD 的精准医学。
