慢性阻塞性肺疾病患者的脂肪酸饮食摄入量及其与第一秒用力呼气容积/用力肺活量的关系。

Dietary intake of fatty acids and its relationship with FEV/FVC in patients with chronic obstructive pulmonary disease.

作者信息

Jiménez-Cepeda Abril, Dávila-Said Giselle, Orea-Tejeda Arturo, González-Islas Dulce, Elizondo-Montes Marcela, Pérez-Cortes Guillermo, Keirns-Davies Candace, Castillo-Aguilar Luis Felipe, Verdeja-Vendrell Leslie, Peláez-Hernández Viridiana, Sánchez-Santillán Rocío Nayelí

机构信息

Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico.

出版信息

Clin Nutr ESPEN. 2019 Feb;29:92-96. doi: 10.1016/j.clnesp.2018.11.015. Epub 2018 Dec 8.

DOI:10.1016/j.clnesp.2018.11.015

PMID:30661707

Abstract

BACKGROUND & AIMS: The deterioration of pulmonary function has been associated with increased levels of systemic inflammation that can be stimulated by consumption of saturated fatty acids and trans fats. We hypothesized that fatty acids intake impact on pulmonary function. However, evidence about the impact of different types of fatty acids on pulmonary function in patients with chronic obstructive pulmonary disease (COPD) is limited and heterogeneous. The aim of this study was to evaluate the association between intake of fatty acids and pulmonary function in patients with COPD.

METHODS

Cross sectional study of patients diagnosed with COPD. The relationship between consumption of fatty acids and the FEV/FVC ratio obtained by spirometry was assessed. Patients with exacerbations during the prior 2 months, diagnosis of asthma or administration of a dietary supplement were excluded.

RESULTS

A simple linear regression showed that for each gram of carbohydrates and total l fatty acids intake, the FEV/FVC ratio decreased -0.03 ml (β: -0.03, 95% CI -0.06 to -0.01, p = 0.008) and -0.009 ml (β: -0.00, 95% CI -0.02 to 0.00, p = 0.031) respectively. Pentadecanoic acid (C15:0) was associated with an increase of 0.47 ml in the FEV/FVC ratio for each milligram intake (β: 0.47, 95% CI 0.04 to 0.91, p = 0.031). Subsequently, when adjusted for calories intake, an increase of 0.53 ml was observed in the FEV/FVC for each milligram of C15:0 fatty acid intake (β:0.53, 95% CI 0.09 to 0.97, p = 0.018).

CONCLUSION

A positive association was observed between pentadecanoic acid and the FEV/FVC ratio with a beneficial effect on patients with COPD.

摘要

背景与目的

肺功能恶化与全身炎症水平升高有关，而饱和脂肪酸和反式脂肪的摄入可能会刺激全身炎症。我们推测脂肪酸摄入会影响肺功能。然而，关于不同类型脂肪酸对慢性阻塞性肺疾病（COPD）患者肺功能影响的证据有限且存在异质性。本研究的目的是评估COPD患者脂肪酸摄入量与肺功能之间的关联。

方法

对诊断为COPD的患者进行横断面研究。评估脂肪酸摄入量与通过肺活量测定法获得的FEV/FVC比值之间的关系。排除前2个月内有病情加重、诊断为哮喘或服用膳食补充剂的患者。

结果

简单线性回归显示，每摄入1克碳水化合物和总脂肪酸，FEV/FVC比值分别下降-0.03毫升（β：-0.03，95%可信区间-0.06至-0.01，p = 0.008）和-0.009毫升（β：-0.00，95%可信区间-0.02至0.00，p = 0.031）。每摄入1毫克十五烷酸（C15:0），FEV/FVC比值增加0.47毫升（β：0.47，95%可信区间0.04至0.91，p = 0.031）。随后，在调整卡路里摄入量后，每摄入1毫克C15:0脂肪酸，FEV/FVC增加0.53毫升（β：0.53，95%可信区间0.09至0.97，p = 0.018）。