部分水解瓜尔胶可抑制SU5416/低氧大鼠模型中肺动脉高压的进展。
Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model.
作者信息
Sanada Takayuki J, Hosomi Koji, Park Jonguk, Naito Akira, Sakao Seiichiro, Tanabe Nobuhiro, Kunisawa Jun, Tatsumi Koichiro, Suzuki Takuji
机构信息
Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) National Institutes of Biomedical Innovation, Health, and Nutrition (NIBIOHN) Osaka Japan.
Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan.
出版信息
Pulm Circ. 2023 Jul 12;13(3):e12266. doi: 10.1002/pul2.12266. eCollection 2023 Jul.
This study investigated the effects of partially hydrolyzed guar gum (PHGG) on the development of pulmonary arterial hypertension using a SU5416/hypoxia rat model. Our results demonstrated that PHGG treatment suppressed the development of pulmonary hypertension and vascular remodeling with an altered gut microbiota composition.
本研究使用SU5416/低氧大鼠模型，研究了部分水解瓜尔胶（PHGG）对肺动脉高压发展的影响。我们的结果表明，PHGG治疗可抑制肺动脉高压的发展和血管重塑，同时肠道微生物群组成发生改变。
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