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部分水解瓜尔胶可抑制SU5416/低氧大鼠模型中肺动脉高压的进展。

Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model.

作者信息

Sanada Takayuki J, Hosomi Koji, Park Jonguk, Naito Akira, Sakao Seiichiro, Tanabe Nobuhiro, Kunisawa Jun, Tatsumi Koichiro, Suzuki Takuji

机构信息

Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) National Institutes of Biomedical Innovation, Health, and Nutrition (NIBIOHN) Osaka Japan.

Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan.

出版信息

Pulm Circ. 2023 Jul 12;13(3):e12266. doi: 10.1002/pul2.12266. eCollection 2023 Jul.

DOI:10.1002/pul2.12266
PMID:37448440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10336776/
Abstract

This study investigated the effects of partially hydrolyzed guar gum (PHGG) on the development of pulmonary arterial hypertension using a SU5416/hypoxia rat model. Our results demonstrated that PHGG treatment suppressed the development of pulmonary hypertension and vascular remodeling with an altered gut microbiota composition.

摘要

本研究使用SU5416/低氧大鼠模型，研究了部分水解瓜尔胶（PHGG）对肺动脉高压发展的影响。我们的结果表明，PHGG治疗可抑制肺动脉高压的发展和血管重塑，同时肠道微生物群组成发生改变。

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本文引用的文献

1
The Role and Mechanism of Gut Microbiota in Pulmonary Arterial Hypertension.肠道微生物群在肺动脉高压中的作用和机制。
Nutrients. 2022 Oct 13;14(20):4278. doi: 10.3390/nu14204278.
2
Revisiting the role of as a therapeutic bacterium.重新审视 作为治疗细菌的作用。
Gut Microbes. 2022 Jan-Dec;14(1):2078619. doi: 10.1080/19490976.2022.2078619.
3
Altered gut microbiota and its association with inflammation in patients with chronic thromboembolic pulmonary hypertension: a single-center observational study in Japan.慢性血栓栓塞性肺动脉高压患者肠道菌群改变及其与炎症的关系：日本单中心观察性研究。
BMC Pulm Med. 2022 Apr 8;22(1):138. doi: 10.1186/s12890-022-01932-0.
4
Water-soluble dietary fiber alleviates cancer-induced muscle wasting through changes in gut microenvironment in mice.水溶性膳食纤维通过改变小鼠肠道微环境缓解癌症引起的肌肉减少症。
Cancer Sci. 2022 May;113(5):1789-1800. doi: 10.1111/cas.15306. Epub 2022 Mar 17.
5
2021 American Thoracic Society BEAR Cage Winning Proposal: Microbiome Transplant in Pulmonary Arterial Hypertension.2021年美国胸科学会熊笼奖获奖提案：肺动脉高压中的微生物群移植
Am J Respir Crit Care Med. 2022 Jan 1;205(1):13-16. doi: 10.1164/rccm.202108-1833ED.
6
Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization.黏膜糖利用菌微生物联合体的合理设计可减少艰难梭菌定植。
Nat Commun. 2020 Oct 9;11(1):5104. doi: 10.1038/s41467-020-18928-1.
7
Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model.肠道微生物群修饰可抑制SU5416/低氧大鼠模型中肺动脉高压的发展。
Pulm Circ. 2020 Aug 27;10(3):2045894020929147. doi: 10.1177/2045894020929147. eCollection 2020 Jul-Sep.
8
Comparison of the fecal microbiota of two monogastric herbivorous and five omnivorous mammals.比较两种单胃草食性和五种杂食性哺乳动物的粪便微生物群。
Anim Sci J. 2020 Jan-Dec;91(1):e13366. doi: 10.1111/asj.13366.
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Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension.肺动脉高压患者肠道微生物组谱的改变。
Hypertension. 2020 Apr;75(4):1063-1071. doi: 10.1161/HYPERTENSIONAHA.119.14294. Epub 2020 Feb 24.
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J Pediatr Surg. 2019 Dec;54(12):2514-2519. doi: 10.1016/j.jpedsurg.2019.08.048. Epub 2019 Sep 2.