Blossia Susan, Tirkey Richa Sasmita, Kingsbury Beena, Yenuberi Hilda, Mahasampath Gowri, Jude John, Benjamin Santosh, Mathews Jiji Elizabeth, Rathore Swati
Department of Obstetrics and Gynaecology, Christian Medical College and Hospital Vellore, Tamil Nadu, India.
Department of Biostatistics, Christian Medical College and Hospital Vellore, Tamil Nadu, India.
J Family Med Prim Care. 2023 May;12(5):953-957. doi: 10.4103/jfmpc.jfmpc_1588_22. Epub 2023 May 31.
There is a very little information known about CRP in term pregnancies. It is a marker that is easily tested and is inexpensive. Although CRP has been used very effectively in diagnosing infection in the neonate, its clinical use and values have not been studied in term pregnancies. The level of CRP that is truly normal or clinically innocuous is not known.
This is a cross-sectional study to compare the CRP levels in antenatal women with PROM and women with normal labor and assess its utility to predict sepsis.
This is a prospective study done over a period of one year and approved by the insititutional ethical committee (IRB. Min. No 11102[OBSERVE] dated 10.01.2018). Sample for CRP was collected from 112 antenatal women with prelabor rupture of membranes within 12 hours of admission (Group A) and from 112 antenatal women in spontaneous labor without rupture of membrane (Group B). CRP samples are processed by nephelometry method.
The median CRP value in Group A is 9.15 and Group B is 7.26, with no statistical difference. Chorioamnionitis, neonatal sepsis, and endometritis were similar in both the groups.
CRP cannot be used as predictor for chorioamnionitis, endometritis, and neonatal sepsis. There was no significant difference in CRP levels between the two groups.
关于足月妊娠时的C反应蛋白（CRP），已知信息非常少。它是一种易于检测且成本低廉的标志物。尽管CRP在诊断新生儿感染方面已得到非常有效的应用，但其在足月妊娠中的临床应用和价值尚未得到研究。真正正常或临床上无害的CRP水平尚不清楚。
这是一项横断面研究，旨在比较胎膜早破的产前妇女与正常分娩妇女的CRP水平，并评估其预测败血症的效用。
这是一项为期一年的前瞻性研究，已获得机构伦理委员会批准（IRB. 最小编号11102[观察]，日期为2018年1月10日）。CRP样本采集自112名入院后12小时内胎膜早破的产前妇女（A组）和112名未破膜自然分娩的产前妇女（B组）。CRP样本采用散射比浊法处理。
A组的CRP中位数为9.15，B组为7.26，无统计学差异。两组的绒毛膜羊膜炎、新生儿败血症和子宫内膜炎情况相似。
CRP不能用作绒毛膜羊膜炎、子宫内膜炎和新生儿败血症的预测指标。两组之间的CRP水平无显著差异。
