致病性感染：一例罕见病例报告及文献综述
Pathogenic infection: A rare case report and literature review.
作者信息
Zhang Jing, Zhu Yingwei, Sun Yuxia, Han Xuewei, Mao Yimin
机构信息
Department of Respiratory Medicine, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
China Aviation Industry Corporation Luoyang Institute of Electro-Optical Devices, Luoyang, China.
出版信息
Heliyon. 2023 Jun 16;9(7):e17183. doi: 10.1016/j.heliyon.2023.e17183. eCollection 2023 Jul.
BACKGROUND
To date, only six cases of infection have been reported, including two ocular cases, three pulmonary cases, and one disseminated case. However, no pulmonary infection cases have been reported in immunocompetent patients without structural pulmonary disease. This study describes a rare case and provides a detailed review of all previous cases.
METHODS
A pulmonary infection caused by in a 64-year-old man with low-grade fever, night sweats, and weight loss was reported. All previously reported cases of infection were searched and reviewed.
RESULTS
The pathogen was identified as using bronchoalveolar lavage fluid (BALF) mNGS, and the current case was successfully treated with trimethoprim-sulfamethoxazole (ST) monotherapy. mNGS and 16S rRNA PCR are standard tests to identify .Conclusion: mNGS has high diagnostic performance for . Further studies are needed to clarify the clinical characteristics and explore more effective treatment protocols for this rare pathogen.
背景
迄今为止，仅报告了6例感染病例，包括2例眼部病例、3例肺部病例和1例播散性病例。然而，在没有结构性肺病的免疫功能正常的患者中，尚未报告肺部感染病例。本研究描述了1例罕见病例，并对所有既往病例进行了详细回顾。
方法
报告1例64岁男性因[具体病原体未给出]引起肺部感染，伴有低热、盗汗和体重减轻。检索并回顾了所有既往报告的[具体病原体未给出]感染病例。
结果
使用支气管肺泡灌洗术（BALF）宏基因组二代测序（mNGS）鉴定病原体为[具体病原体未给出]，本例患者采用复方磺胺甲恶唑（ST）单药治疗成功治愈。mNGS和16S rRNA聚合酶链反应（PCR）是鉴定[具体病原体未给出]的标准检测方法。结论：mNGS对[具体病原体未给出]具有较高的诊断效能。需要进一步研究以阐明其临床特征，并探索针对这种罕见病原体更有效的治疗方案。
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