Tsai Jefferson, Kaneko Kaichi, Suh Andrew J, Bockman Richard, Park-Min Kyung-Hyun
Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Division of Rheumatology, Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.
J Bone Metab. 2023 May;30(2):127-140. doi: 10.11005/jbm.2023.30.2.127. Epub 2023 May 31.
Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied. Moreover, it has been well established that osteoclasts are differentiated in vitro from myeloid cells such as bone marrow macrophages or monocytes. The concept showing that osteoclasts are derived from a specific population (named osteoclast precursor cells [OCPs]) among myeloid cells has been long hypothesized. However, the specific precursor population of osteoclasts is not clearly defined yet. A growing body of work provides evidence of the developmental origin and lifespan of murine osteoclasts, particularly in vivo. Here, we review the emerging evidence that supports the existence of OCPs and discuss current insights into their identity.
破骨细胞是多核骨吸收细胞，在骨骼健康与疾病的重塑过程中起着关键作用。自1873年破骨细胞被发现以来，破骨细胞的结构和功能以及破骨细胞生成的分子和细胞机制已得到广泛研究。此外，已经明确破骨细胞可在体外由骨髓巨噬细胞或单核细胞等髓系细胞分化而来。长期以来一直有这样的假说，即破骨细胞来源于髓系细胞中的特定群体（称为破骨细胞前体细胞[OCPs]）。然而，破骨细胞的具体前体群体尚未明确界定。越来越多的研究工作提供了小鼠破骨细胞发育起源和寿命的证据，特别是在体内的证据。在此，我们综述支持OCPs存在的新证据，并讨论目前对其身份的认识。
