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一名 12 岁男孩因隐匿性慢性心肌炎导致严重心肌纤维化而猝死。

Sudden death of a 12-year-old boy with severe myocardial fibrosis due to inapparent chronic myocarditis.

机构信息

Institute of Legal Medicine, University Hospital Bonn, Stiftsplatz 12, Bonn, 53111, Germany.

Institute of Legal Medicine, Medical University of Innsbruck, Müllerstr. 44, Innsbruck, 6020, Austria.

出版信息

Forensic Sci Med Pathol. 2024 Jun;20(2):742-745. doi: 10.1007/s12024-023-00670-x. Epub 2023 Jul 14.

DOI:10.1007/s12024-023-00670-x
PMID:37450168
Abstract

Sudden death due to unknown cardiac disease in children is an unusual occurrence. An apparently healthy 12-year-old boy without any physical restrictions collapsed suddenly and died despite cardiopulmonary resuscitation. The main autopsy finding was extensive scarring of the myocardium, especially the interventricular septum. This extensive scarring was exceptional for the young age. Histologically, replacement-type fibrosis with patchy lymphomonocytic infiltrate and infiltration by macrophages were observed. The case was diagnosed as chronic myocarditis, which may have progressed to dilated cardiomyopathy with inflammation or inflammatory cardiomyopathy.

摘要

儿童因不明原因的心脏疾病而突然死亡是一种罕见的情况。一名看似健康的 12 岁男孩，没有任何身体限制，突然倒地并死亡，尽管进行了心肺复苏。主要的尸检发现是心肌，特别是室间隔的广泛瘢痕形成。这种广泛的瘢痕形成对于这个年轻的年龄来说是异常的。组织学上，观察到替代性纤维化，伴有斑块状淋巴单核细胞浸润和巨噬细胞浸润。该病例被诊断为慢性心肌炎，可能已经发展为炎症或炎症性心肌病导致的扩张型心肌病。

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