Autonomic reactivity during acute social stress: exploratory investigation of an interaction by threat interpretation bias and emotion regulation difficulties.

: This preliminary study examined the interactive influences of interpretation bias and emotion dysregulation in predicting autonomic stress response.: Participants ( = 72 college students; ages 18-25, 70% female, 47% Hispanic/Latinx), completed a performance-based assessment of threat interpretation bias and self-report measures of emotion regulation difficulties. Electrodermal activity (EDA; skin conductance level) was collected while participants completed a standardized psychosocial stressor task.: Interpretation bias and emotion regulation difficulties interacted to predict EDA trajectories ( = 0.054, SE = .001, CI:.007, .002,  < .001) during acute stress: presence of interpretation bias toward threat ( = 6.950, SE = 2.826, CI: 1.407, 12.488,  = .013) emotion regulation difficulties ( = 9.387, SE = 3.685, CI: 2.141, 16.636,  = .011) was associated with greater reactivity and poorer recovery; presence of was associated with the lowest resting state EDA and blunted reactivity ( = 1.340, SE = 3.085, CI: -4.721, 7.407,  = .66).: Preliminary findings support interpretation bias and emotion regulation difficulties, and their distinct interactive patterns, as predictors of autonomic reactivity trajectories during stress. Interpretation bias modification and emotion regulation skills may be important intervention targets for common psychological conditions that are influenced by aberrant psychophysiological processes.