School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Institute of Animal Husbandry and Veterinary, Wuhan Academy of Agricultural Sciences, China.
Colloids Surf B Biointerfaces. 2023 Sep;229:113444. doi: 10.1016/j.colsurfb.2023.113444. Epub 2023 Jul 7.
Bacterial infection is a huge threat to the health of human beings and animals. The abuse of antibiotics have led to the occurrence of bacterial multidrug resistance, which have become a difficult problem in the treatment of clinical infections. Given the outstanding advantages of nanodrug delivery systems in cancer treatment, many scholars have begun to pay attention to their application in bacterial infections. However, due to the similarity of the microenvironment between bacterial infection lesions and cancer sites, the targeting and accuracy of traditional microenvironment-responsive nanocarriers are questionable. Therefore, finding new specific targets has become a new development direction of nanocarriers in bacterial prevention and treatment. This article reviews the infectious microenvironment induced by bacteria and a series of virulence factors of common pathogenic bacteria and their physiological functions, which may be used as potential targets to improve the targeting accuracy of nanocarriers in lesions.
细菌感染是人类和动物健康的巨大威胁。抗生素的滥用导致了细菌的多药耐药性的发生，这成为临床感染治疗的难题。鉴于纳米药物递送系统在癌症治疗方面的突出优势，许多学者已经开始关注它们在细菌感染中的应用。然而，由于细菌感染病变和癌症部位的微环境相似，传统的微环境响应型纳米载体的靶向性和准确性值得怀疑。因此，寻找新的特异性靶点已成为纳米载体在细菌防治方面的新的发展方向。本文综述了细菌感染诱导的感染微环境以及常见致病菌的一系列毒力因子及其生理功能，这些可能可以作为提高纳米载体在病变部位靶向准确性的潜在靶点。
