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使用可注射富血小板纤维蛋白和微针技术进行薄龈型牙龈增量术

Gingival Augmentation in the Thin Phenotype Using Injectable Platelet-Rich Fibrin and Microneedling.

作者信息

Adhikary Rajnandini, Mohan Prerna, Wadhawan Amit, Tyagi Prashant

机构信息

Department of Periodontology, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, IND.

出版信息

Cureus. 2023 Jun 14;15(6):e40435. doi: 10.7759/cureus.40435. eCollection 2023 Jun.

DOI:10.7759/cureus.40435
PMID:37456469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10349171/
Abstract

Objective This study set out to examine the results of microneedling (MN) with and without injectable platelet-rich fibrin (i-PRF) in treating individuals with thin periodontal phenotypes, specifically focusing on the effects on gingival thickness (GT) and keratinized tissue width (KTW). Materials and methods This was a split-mouth study involving 32 healthy patients with 64 sites having thin phenotypes classified into two groups. On the one side, i-PRF was injected (Group A), while on the other side (Group B), MN along with i-PRF was used at intervals of 10 days for a month. GT and KTW were measured at baseline, three months, and six months. The parameters were compared intra and intergroup-wise at baseline, three months, and six months using the IBM SPSS Statistics software version 24 (IBM Corp., Armonk, NY) and the chi-square test. Results The findings revealed that when comparing Group A, which received just i-PRF, to Group B, which had i-PRF in conjunction with MN, there was a statistically significant increase in GT in Group B. Conclusions This is a novel method in that it does not need surgical innervations to expand the gingiva in breadth or thickness. Although MN's neoangiogenesis impact contributed to thicker gingiva, i-PRF showed a greater capacity for the release of several growth factors.

摘要

目的 本研究旨在探讨微针治疗(MN)联合或不联合注射用富血小板纤维蛋白(i-PRF)治疗牙周组织菲薄型个体的效果,特别关注其对牙龈厚度(GT)和角化组织宽度(KTW)的影响。材料和方法 这是一项双侧对照研究,纳入32例健康患者,共64个牙周组织菲薄型位点,分为两组。一侧注射i-PRF(A组),另一侧(B组)采用微针治疗联合i-PRF,每隔10天治疗1次,共治疗1个月。在基线、3个月和6个月时测量GT和KTW。使用IBM SPSS Statistics软件24版(IBM公司,纽约州阿蒙克)和卡方检验对基线、3个月和6个月时的参数进行组内和组间比较。结果 研究结果显示,仅接受i-PRF治疗的A组与接受i-PRF联合微针治疗的B组相比,B组的GT有统计学意义的增加。结论 这是一种新方法,无需手术干预即可在宽度或厚度上扩展牙龈。虽然微针治疗的新生血管形成作用有助于牙龈增厚,但i-PRF显示出更强的多种生长因子释放能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/34e5690fd2c5/cureus-0015-00000040435-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/315bea2a7b5a/cureus-0015-00000040435-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/525c3da56242/cureus-0015-00000040435-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/3ecf765146f6/cureus-0015-00000040435-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/34e5690fd2c5/cureus-0015-00000040435-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/315bea2a7b5a/cureus-0015-00000040435-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/525c3da56242/cureus-0015-00000040435-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/3ecf765146f6/cureus-0015-00000040435-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/10349171/34e5690fd2c5/cureus-0015-00000040435-i04.jpg

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本文引用的文献

1
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2
Microneedles and Nanopatches-Based Delivery Devices in Dentistry.牙科中基于微针和纳米贴片的给药装置
Discoveries (Craiova). 2020 Sep 30;8(3):e116. doi: 10.15190/d.2020.13.
3
Gingival thickness assessment at the mandibular incisors with four methods: A cross-sectional study.四种方法评估下颌切牙的牙龈厚度:一项横断面研究。
Gingival Augmentation Using Injectable Platelet-Rich Fibrin (i-PRF)-A Systematic Review of Randomized Controlled Trials.
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J Clin Med. 2024 Sep 20;13(18):5591. doi: 10.3390/jcm13185591.
4
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Cureus. 2024 Jun 8;16(6):e61958. doi: 10.7759/cureus.61958. eCollection 2024 Jun.
5
Thermographic examination of gingival phenotypes: correlation between morphological and thermal parameters.牙龈表型的热成像检查:形态学参数与热学参数之间的相关性
Clin Oral Investig. 2023 Dec;27(12):7705-7714. doi: 10.1007/s00784-023-05361-z. Epub 2023 Nov 4.
J Periodontol. 2018 Nov;89(11):1300-1309. doi: 10.1002/JPER.18-0125. Epub 2018 Aug 20.
4
Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.系统疾病及发育和获得性状况的牙周表现:2017 年牙周病和种植体周围病分类世界研讨会第 3 工作组的共识报告。
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5
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6
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Indian Dermatol Online J. 2016 Jul-Aug;7(4):244-54. doi: 10.4103/2229-5178.185468.
7
Gingival biotype characterization--a study in a Portuguese sample.牙龈生物型特征——一项针对葡萄牙样本的研究。
Int J Esthet Dent. 2015 Winter;10(4):534-46.
8
Gingival biotype: a review.牙龈生物型:综述
Gen Dent. 2013 Jul;61(4):14-7.
9
Relationships between different tooth shapes and patient's periodontal phenotype.不同牙齿形状与患者牙周表型的关系。
J Periodontal Res. 2013 Oct;48(5):657-62. doi: 10.1111/jre.12057. Epub 2013 Feb 27.
10
Coronally advanced flap procedure for root coverage. Is flap thickness a relevant predictor to achieve root coverage? A 19-case series.用于牙根覆盖的冠向推进瓣手术。瓣厚度是实现牙根覆盖的相关预测因素吗?一项包含19个病例的系列研究。
J Periodontol. 1999 Sep;70(9):1077-84. doi: 10.1902/jop.1999.70.9.1077.