Fang Huan, Xu Jie, Ma Hailin, Liu Jiaqi, Xing Erpai, Cheng Yuen Yee, Wang Hong, Nie Yi, Pan Bo, Song Kedong
State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China.
Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, Henan, China.
Int J Bioprint. 2023 Mar 18;9(5):757. eCollection 2023.
The skin plays an important role in vitamin D synthesis, humoral balance, temperature regulation, and waste excretion. Due to the complexity of the skin, fluids loss, bacterial infection, and other life-threatening secondary complications caused by skin defects often lead to the damage of skin functions. 3D bioprinting technology, as a customized and precise biomanufacturing platform, can manufacture dressings and tissue engineering scaffolds that accurately simulate tissue structure, which is more conducive to wound healing. In recent years, with the development of emerging technologies, an increasing number of 3D-bioprinted wound dressings and skin tissue engineering scaffolds with multiple functions, such as antibacterial, antiinflammatory, antioxidant, hemostatic, and antitumor properties, have significantly improved wound healing and skin treatment. In this article, we review the process of wound healing and summarize the classification of 3D bioprinting technology. Following this, we shift our focus on the functional materials for wound dressing and skin tissue engineering, and also highlight the research progress and development direction of 3D-bioprinted multifunctional wound healing materials.
皮肤在维生素D合成、体液平衡、体温调节及废物排泄中发挥着重要作用。由于皮肤结构复杂,皮肤缺损导致的体液流失、细菌感染及其他危及生命的继发性并发症常致使皮肤功能受损。3D生物打印技术作为一种定制化的精准生物制造平台,能够制造出精确模拟组织结构的敷料和组织工程支架,更有利于伤口愈合。近年来,随着新兴技术的发展,越来越多具有抗菌、抗炎、抗氧化、止血及抗肿瘤等多种功能的3D生物打印伤口敷料和皮肤组织工程支架显著改善了伤口愈合和皮肤治疗效果。在本文中,我们回顾了伤口愈合过程并总结了3D生物打印技术的分类。在此基础上,我们将重点转向伤口敷料和皮肤组织工程的功能材料,并突出3D生物打印多功能伤口愈合材料的研究进展及发展方向。
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